Nagasaki Sumito, Ishii Keisuke, Murakami Yoshitaka, Tsutsui Anna, Hidaka Nobuhiro, Takahashi Hironori, Ichizuka Kiyotake, Miyakoshi Kei, Miura Kiyonori, Miyashita Susumu, Kamei Yoshimasa, Nakata Masahiko
Department of Obstetrics and Gynecology, Toho University Omori Medical Center, 6-11-1, Omorinishi, Ota-ku, Tokyo, 143-8540, Japan.
Department of Maternal Fetal Medicine, Osaka Women's and Children's Hospital, 840, Murodo-cho , Izumi-shi, Osaka, 594-1101, Japan.
Sci Rep. 2025 Aug 20;15(1):30560. doi: 10.1038/s41598-025-14508-9.
Given the decline in birthweights over the past 30 years in Japan and advancements in ultrasound technology, this study aimed to establish new reference values for ultrasound fetal biometry in Japan and to compare them with international and Asian studies. We conducted a cross-sectional prospective study involving singleton pregnancies who received prenatal checkups at obstetric facilities across Japan. During routine prenatal care, ultrasound measurements-biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length (FL)-were recorded. Estimated fetal weight (EFW) was calculated using both the Shinozuka formula, commonly used in Japan, and the Hadlock-3 formula, widely used internationally. Using the collected data, we developed gestational-age-specific reference values for BPD, HC, AC, FL, and EFW by applying best-fitted fractional polynomial regression, and compared them with existing international standards and reference values from other Asian countries. The mean EFW calculated by the Hadlock formula in this study tended to be smaller than that reported in other international studies, and BPD, HC, AC, and FL were also generally smaller than those observed in other Asian references. These findings indicate that fetal biometry values in the Japanese population are smaller not only than international standards but also compared with those from other Asian countries, and suggest that these population-specific data may contribute to improving the accuracy of fetal growth assessment in Japan and other parts of Asia.
鉴于过去30年日本出生体重下降以及超声技术的进步，本研究旨在建立日本超声胎儿生物测量的新参考值，并将其与国际和亚洲研究进行比较。我们开展了一项横断面前瞻性研究，纳入了在日本各地产科机构接受产前检查的单胎妊娠孕妇。在常规产前检查期间，记录超声测量值——双顶径（BPD）、头围（HC）、腹围（AC）和股骨长度（FL）。使用日本常用的筱冢公式和国际广泛使用的哈德洛克-3公式计算估计胎儿体重（EFW）。利用收集到的数据，通过应用最佳拟合分数多项式回归，我们制定了BPD、HC、AC、FL和EFW的孕周特异性参考值，并将其与现有的国际标准以及其他亚洲国家的参考值进行比较。本研究中通过哈德洛克公式计算的平均EFW往往低于其他国际研究报告的值，BPD、HC、AC和FL通常也低于其他亚洲参考值。这些发现表明，日本人群的胎儿生物测量值不仅低于国际标准，而且与其他亚洲国家相比也较低，这表明这些特定人群的数据可能有助于提高日本和亚洲其他地区胎儿生长评估的准确性。
