Department of Obstetrics and Gynecology, HsinChu MacKay Memorial Hospital, HsinChu, Taiwan.
Department of Obstetrics and Gynecology, HsinChu MacKay Memorial Hospital, HsinChu, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
Taiwan J Obstet Gynecol. 2022 Sep;61(5):794-799. doi: 10.1016/j.tjog.2022.06.003.
The purpose of this study was to establish a new reference chart and growth standards for fetal biometry in Taiwan.
2047 singleton pregnancies were enrolled in this study with 15,813 fetal scans between 18 and 40 gestational weeks. A reference chart and normal range for fetal biparietal diameter (BPD), abdominal circumference (AC) and femur length (FL) was established by longitudinal quantile regression model. 330 women with comorbidities including gestational hypertension, preeclampsia and gestational diabetes were excluded and 1717 pregnant women were enrolled for the growth standard.
The new reference values were significantly larger across all gestational ages compared with the prior National Taiwan University reference chart in 1983. Compared with Intergrowth-21st, the BPD was larger at 18-23 weeks, the AC was larger at 18-24 weeks and the FL was larger at 18-36 weeks whereas they were all smaller at 29-40 weeks for the BPD, at 32-40 weeks for the AC and at 38-40 weeks for the FL. A quantile regression equation of biometry was established. BPD, AC, and FL had weekly growth of 2.5, 9.87 and 2.15 mm. Prepregnancy body weight, height, age, and gestational diabetes increased fetal size. Both gestational and chronic hypertension decreased fetal size.
To promote maternal-fetal safety, a new reference chart and growth standard for fetal biometry is necessary to measure fetal growth.
本研究旨在建立台湾胎儿生物测量的新参考图表和生长标准。
本研究纳入了 2047 例单胎妊娠，在 18 至 40 孕周进行了 15813 次胎儿扫描。通过纵向分位数回归模型建立了胎儿双顶径（BPD）、腹围（AC）和股骨长（FL）的参考图表和正常范围。排除了 330 例患有合并症（包括妊娠期高血压、子痫前期和妊娠期糖尿病）的妇女，纳入了 1717 例孕妇进行生长标准研究。
与 1983 年国立台湾大学的参考图表相比，新的参考值在所有孕龄均显著增大。与 Intergrowth-21st 相比，18-23 周时 BPD 较大，18-24 周时 AC 较大，18-36 周时 FL 较大，而 29-40 周时 BPD、32-40 周时 AC 和 38-40 周时 FL 均较小。建立了生物测量的分位数回归方程。BPD、AC 和 FL 的每周生长速度分别为 2.5、9.87 和 2.15mm。孕前体重、身高、年龄和妊娠期糖尿病均增加了胎儿大小。妊娠期和慢性高血压均降低了胎儿大小。
为了促进母婴安全，有必要制定新的胎儿生物测量参考图表和生长标准来衡量胎儿生长。
