Giarratana Anna O
Nuclear Medicine and Molecular Imaging Section, Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States.
Front Neurol. 2025 Aug 5;16:1637243. doi: 10.3389/fneur.2025.1637243. eCollection 2025.
This review examines the role of positron emission tomography (PET) imaging tracers in advancing our understanding of traumatic brain injury (TBI) induced neurodegeneration and the therapeutic targets they help to identify. It focuses on tracers used to evaluate post-TBI alterations in metabolism, amyloid, tau, neuroinflammation, and neurotransmitter systems. These molecular imaging tools provide critical insights into pathophysiological processes such as disrupted glucose metabolism, amyloid deposition, tau accumulation, chronic neuroinflammatory responses, and neurotransmitter dysregulation. The review also explores how these tracers, as imaging biomarkers, may guide future therapeutic strategies. Finally, it discusses the challenges and opportunities associated with integrating PET imaging into TBI diagnosis, longitudinal monitoring, and treatment planning.
本综述探讨了正电子发射断层扫描（PET）成像示踪剂在增进我们对创伤性脑损伤（TBI）所致神经退行性变的理解以及它们所帮助识别的治疗靶点方面的作用。它聚焦于用于评估TBI后代谢、淀粉样蛋白、tau蛋白、神经炎症和神经递质系统变化的示踪剂。这些分子成像工具为诸如葡萄糖代谢紊乱、淀粉样蛋白沉积、tau蛋白积累、慢性神经炎症反应和神经递质失调等病理生理过程提供了关键见解。该综述还探讨了这些示踪剂作为成像生物标志物如何可能指导未来的治疗策略。最后，它讨论了将PET成像整合到TBI诊断、纵向监测和治疗规划中所面临的挑战和机遇。
