Haonan Chen, Shuhan Zang, Runlei Zhang, Peilin Chen, Shengxian Wu
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Peking University International Hospital, Beijing, China.
J Med Biochem. 2025 Jul 4;44(4):895-904. doi: 10.5937/jomb0-57208.
BACKGROUND: This randomised controlled trial aimed to investigate the relationship between antioxidant markers (Superoxide Dismutase [SOD], Glutathione [GSH], Catalase, and Nitric Oxide [NO]) and the severity of ischemic stroke in affected individuals. METHODS: A single-blind randomised controlled trial was conducted from June 2022 to November 2024, including 364 patients aged 45-80 years diagnosed with ischemic stroke. Participants were randomly divided into two groups: Group A (n=193) received standard stroke rehabilitation therapy, while Group B (n=171) received additional antioxidant support. Serum levels of SOD, GSH, Catalase, and NO were measured. Stroke severity was evaluated using the modified Rankin Scale (mRS) and NIH Stroke Scale (NIHSS), with follow-up assessments at 2, 4, and 6 months post-treatment. RESULTS: Among the 364 participants, 203 (55.7%) were male, and 161 (44.3%) were female, with a mean age of 67.3±12.2 years. Serum SOD levels were higher in the experimental group (16.3±3.7 U/mL) compared to the control group (12.5±4.1 U/mL, p=0.014). GSH levels were also significantly higher in the experimental group (178±31 mmol/L) than in the control group (145±26 mmol/L, p=0.032). NO levels were higher in the experimental group (42.1±8.6 mmol/L) than in the control group (35.4±7.3 mmol/L, p=0.021). Catalase levels were 52.3±11.1 U/mL in the experimental group and 49.6±10.2 U/mL in the control group, with no significant difference between the groups (p=0.213). Significant inverse correlations were found between SOD, GSH, and NO levels and stroke severity (p<0.05), but catalase showed no such correlation (p=0.513). CONCLUSIONS: This study identified a significant relationship between higher levels of SOD, GSH, and NO and improved stroke recovery, whereas catalase did not exhibit a meaningful association with stroke severity or functional outcomes. These findings highlight the potential role of specific antioxidant markers in stroke prognosis and recovery while suggesting that catalase may not play a critical role in ischemic stroke outcomes.
背景：这项随机对照试验旨在研究抗氧化标志物（超氧化物歧化酶[SOD]、谷胱甘肽[GSH]、过氧化氢酶和一氧化氮[NO]）与受影响个体缺血性中风严重程度之间的关系。 方法：于2022年6月至2024年11月进行了一项单盲随机对照试验，纳入364例年龄在45 - 80岁之间诊断为缺血性中风的患者。参与者被随机分为两组：A组（n = 193）接受标准中风康复治疗，而B组（n = 171）接受额外的抗氧化支持。测量血清中SOD、GSH、过氧化氢酶和NO的水平。使用改良Rankin量表（mRS）和美国国立卫生研究院卒中量表（NIHSS）评估中风严重程度，并在治疗后2、4和6个月进行随访评估。 结果：在364名参与者中，203名（55.7%）为男性，161名（44.3%）为女性，平均年龄为67.3±12.2岁。与对照组（12.5±4.1 U/mL，p = 0.014）相比，实验组血清SOD水平更高（16.3±3.7 U/mL）。实验组GSH水平（178±31 mmol/L）也显著高于对照组（145±26 mmol/L，p = 0.032）。实验组NO水平（42.1±8.6 mmol/L）高于对照组（35.4±7.3 mmol/L，p = 0.021）。实验组过氧化氢酶水平为52.3±11.1 U/mL，对照组为49.6±10.2 U/mL，两组之间无显著差异（p = 0.213）。发现SOD、GSH和NO水平与中风严重程度之间存在显著负相关（p<0.05），但过氧化氢酶未显示出这种相关性（p = 0.513）。 结论：本研究确定了较高水平的SOD、GSH和NO与中风恢复改善之间存在显著关系，而过氧化氢酶与中风严重程度或功能结局无明显关联。这些发现突出了特定抗氧化标志物在中风预后和恢复中的潜在作用，同时表明过氧化氢酶可能在缺血性中风结局中不发挥关键作用。
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