VanderPluym Christina, Kobayashi Ryan, Rivkin Michael
Heart Center, Boston Children's Hospital, Harvard School of Medicine, Boston, MA.
Department of Neurology, Boston Children's Hospital, Harvard School od Medicine, Boston, MA.
JHLT Open. 2025 Jul 17;10:100348. doi: 10.1016/j.jhlto.2025.100348. eCollection 2025 Nov.
Stroke continues to be one of the most significant hemocompatibility related adverse event in pediatric ventricular assist device support. Tremendous gains have been made in reducing the incidence of stroke across all ages, diagnoses and device types. However there still remains noticeable differences in the hemocompatibility of device types, with paracorporeal continuous and pulsatile flow associated with higher rates of ischemic stroke as compared to intracorporeal devices. In this review article, we discuss the landscape of pediatric stroke in mechanical circulatory support focusing on; pathophysiology of stroke in this heightened risk population, past and present incidence of stroke, stroke diagnosis and acute stroke management.
中风仍然是小儿心室辅助装置支持中与血液相容性相关的最重要不良事件之一。在降低所有年龄段、诊断类型和装置类型的中风发生率方面已经取得了巨大进展。然而，不同装置类型的血液相容性仍存在明显差异，与体内装置相比，体外持续和搏动性血流与更高的缺血性中风发生率相关。在这篇综述文章中，我们讨论了机械循环支持下小儿中风的情况，重点关注；这一高风险人群中风的病理生理学、过去和现在的中风发生率、中风诊断和急性中风管理。
