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Aptamer-conjugation targets decoy-ODN-therapeutics to liver fibrosis.

作者信息

Picard Larissa W, Jiang Ziwen

机构信息

Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, TX 75080, USA.

出版信息

Mol Ther Nucleic Acids. 2025 Aug 12;36(3):102660. doi: 10.1016/j.omtn.2025.102660. eCollection 2025 Sep 9.

DOI:10.1016/j.omtn.2025.102660
PMID:40838191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12361974/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d408/12361974/6427d52eee08/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d408/12361974/6427d52eee08/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d408/12361974/6427d52eee08/gr1.jpg

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本文引用的文献

1
Hepatic-stellate-cell-targeted delivery of PU.1 decoy ODN by Apt-Tan attenuates liver fibrosis in mice.通过Apt-Tan将PU.1诱饵寡核苷酸靶向递送至肝星状细胞可减轻小鼠肝纤维化。
Mol Ther Nucleic Acids. 2025 Jun 16;36(3):102607. doi: 10.1016/j.omtn.2025.102607. eCollection 2025 Sep 9.
2
An update on animal models of liver fibrosis.肝纤维化动物模型的最新进展。
Front Med (Lausanne). 2023 Mar 23;10:1160053. doi: 10.3389/fmed.2023.1160053. eCollection 2023.
3
Aptamer-Based Targeted Delivery of Functional Nucleic Acids.基于适配体的靶向递呈功能性核酸。
J Am Chem Soc. 2023 Apr 12;145(14):7677-7691. doi: 10.1021/jacs.3c00841. Epub 2023 Mar 29.
4
SELEX: Critical factors and optimization strategies for successful aptamer selection.SELEX:成功的适体筛选的关键因素和优化策略。
Biotechnol Appl Biochem. 2022 Oct;69(5):1771-1792. doi: 10.1002/bab.2244. Epub 2021 Sep 3.
5
Recent trends of NFκB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases.基于 NFκB 诱饵寡脱氧核苷酸的纳米治疗在肺部疾病中的最新研究进展。
J Control Release. 2021 Sep 10;337:629-644. doi: 10.1016/j.jconrel.2021.08.010. Epub 2021 Aug 8.
6
Liver fibrosis: Pathophysiology and clinical implications.肝纤维化:病理生理学与临床意义。
WIREs Mech Dis. 2021 Jan;13(1):e1499. doi: 10.1002/wsbm.1499. Epub 2020 Jul 26.
7
Cell-SELEX, an Effective Way to the Discovery of Biomarkers and Unexpected Molecular Events.细胞指数富集的配体系统进化技术(Cell-SELEX),一种发现生物标志物和意外分子事件的有效方法。
Adv Biosyst. 2019 Dec;3(12):e1900193. doi: 10.1002/adbi.201900193. Epub 2019 Nov 12.
8
Cellular Uptake Evaluation of Amphiphilic Polymer Assemblies: Importance of Interplay between Pharmacological and Genetic Approaches.细胞摄取评价两亲聚合物组装体:药理学和遗传学方法相互作用的重要性。
Biomacromolecules. 2019 Dec 9;20(12):4407-4418. doi: 10.1021/acs.biomac.9b01073. Epub 2019 Nov 5.
9
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.肝纤维化:病理生理学、发病机制靶点和临床问题。
Mol Aspects Med. 2019 Feb;65:37-55. doi: 10.1016/j.mam.2018.09.002. Epub 2018 Sep 13.
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Transcription factor decoy technology: A therapeutic update.转录因子诱饵技术:治疗进展
Biochem Pharmacol. 2017 Nov 15;144:29-34. doi: 10.1016/j.bcp.2017.06.122. Epub 2017 Jun 19.