Wu ShuTing, Wang XinXin, Xing WenBo, Li FenYao, Liang Ming, Li KeShen, He Yan, Wang JianMing
Institute of Regenerative and Translational Medicine, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.
Department of Hepatobiliary and Pancreatic Surgery, Tianyou Hospital, Wuhan University of Science and Technology, Wuhan, China.
Front Med (Lausanne). 2023 Mar 23;10:1160053. doi: 10.3389/fmed.2023.1160053. eCollection 2023.
The development of liver fibrosis primarily determines quality of life as well as prognosis. Animal models are often used to model and understand the underlying mechanisms of human disease. Although organoids can be used to simulate organ development and disease, the technology still faces significant challenges. Therefore animal models are still irreplaceable at this stage. Currently, models of liver fibrosis can be classified into five categories based on etiology: chemical, dietary, surgical, transgenic, and immune. There is a wide variety of animal models of liver fibrosis with varying efficacy, which have different implications for proper understanding of the disease and effective screening of therapeutic agents. There is no high-quality literature recommending the most appropriate animal models. In this paper, we will describe the progress of commonly used animal models of liver fibrosis in terms of their development mechanisms, applications, advantages and disadvantages, and recommend appropriate animal models for different research purposes.
肝纤维化的发展主要决定生活质量以及预后。动物模型常被用于模拟和理解人类疾病的潜在机制。尽管类器官可用于模拟器官发育和疾病，但该技术仍面临重大挑战。因此，动物模型在现阶段仍然不可替代。目前，基于病因，肝纤维化模型可分为五类：化学性、饮食性、手术性、转基因性和免疫性。有各种各样疗效各异的肝纤维化动物模型，它们对于正确理解疾病和有效筛选治疗药物具有不同的意义。目前尚无高质量文献推荐最合适的动物模型。在本文中，我们将从常用肝纤维化动物模型的发展机制、应用、优缺点方面描述其进展，并针对不同研究目的推荐合适的动物模型。
