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[经动脉关节周围栓塞术(TAPE)——从疼痛到无声:TAPE作为骨关节炎的一种新的局部治疗选择及未来用于炎性风湿性关节疾病]

[Transarterial periarticular embolization (TAPE)-From pain to silence: TAPE as a new local option for osteoarthritis and in the future for inflammatory rheumatic joint diseases].

作者信息

Pfeil Alexander, Pflug Carolin, Wolf Gunter, Teichgräber Ulf, Aschenbach René

机构信息

Rheumazentrum (G-BA-Kriterien) sowie Sektion Rheumatologie und Osteologie, Klinik für Innere Medizin III, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Jena, Deutschland.

出版信息

Z Rheumatol. 2025 Aug 21. doi: 10.1007/s00393-025-01708-x.

Abstract

Transarterial periarticular embolization (TAPE) is a novel interventional procedure for local pain therapy in osteoarthritis. The reduction of local hypervascularization is achieved by supraselective embolization of periarticular arteries using embolic agents. The procedure described herein results in a reduction in both pain and the use of analgesics. The drug was originally developed for the treatment of knee osteoarthritis and initial small studies and case reports indicated that it was effective for other joints, including the fingers and shoulders. In the domain of rheumatology TAPE opens up new therapeutic perspectives, particularly for cases of treatment-resistant monoarthritis and arthritis associated with checkpoint inhibitors.

摘要

经动脉关节周围栓塞术(TAPE)是一种用于骨关节炎局部疼痛治疗的新型介入手术。通过使用栓塞剂对关节周围动脉进行超选择性栓塞来实现局部血管过度增生的减少。本文所述的手术可减轻疼痛并减少镇痛药的使用。该药物最初是为治疗膝骨关节炎而研发的,最初的小型研究和病例报告表明它对包括手指和肩部在内的其他关节也有效。在风湿病领域,TAPE开辟了新的治疗前景,特别是对于难治性单关节炎和与检查点抑制剂相关的关节炎病例。

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