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致蝇蛆病的苍蝇——旧大陆螺旋锥蝇(Chrysomya bezziana)的基因组。

Genome of the Myiasis-Causing Fly Chrysomya bezziana, the Old-World Screwworm.

作者信息

Cunha Vanessa A S, Ferreira Diniz L, Mariano-Martins Pedro, Nefho Farlin, Purwanto Eko Setyo, Sawitri Dyah Haryuningtyas, Torres Tatiana Teixeira, Wardhana April H

机构信息

Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, SP 05508-090, Brazil.

Research Centre for Veterinary Science, Organization Research for Health, The National Research and Innovation Agency. BRIN, Cibinong, West Java Province 16911, Indonesia.

出版信息

Genome Biol Evol. 2025 Jul 30;17(8). doi: 10.1093/gbe/evaf121.

Abstract

Chrysomya bezziana, the Old-World Screwworm, is a parasitic blowfly that causes myiasis, an infestation where larvae feed on live tissues of vertebrate hosts. Myiasis caused by C. bezziana poses a threat for public health and livestock economy in Asia with a potential risk of global spread by human travelers and animals. Genome resources for this parasite are urgently needed as these can facilitate the development of novel control methods to mitigate the impact of C. bezziana on public health and livestock industries. Here, we present the first genome assembly and annotation for C. bezziana. The genome exhibits high-quality with a size of 472 Mb and an N50 of 1.8 Mb and 98.4% of BUSCO single and 0.5% of duplicated genes, showing high completeness and haploid resolution. This initiative, when combined with other blowfly genomes available, will contribute to the ongoing effort to understand the evolutionary origin and molecular underpinnings of parasitic behavior in blowflies. Furthermore, it will also contribute to the development of pest management strategies to control the spread and the impact of this harmful parasite.

摘要

旧大陆螺旋蝇(Chrysomya bezziana)是一种寄生性丽蝇,可引发蝇蛆病,即幼虫寄生于脊椎动物宿主的活体组织内。由旧大陆螺旋蝇引起的蝇蛆病对亚洲的公共卫生和畜牧业经济构成威胁,存在通过人类旅行者和动物在全球传播的潜在风险。迫切需要该寄生虫的基因组资源,因为这有助于开发新的控制方法,以减轻旧大陆螺旋蝇对公共卫生和畜牧业的影响。在此,我们展示了首个旧大陆螺旋蝇的基因组组装和注释。该基因组质量很高,大小为472兆碱基,N50为1.8兆碱基,98.4%的BUSCO单拷贝基因和0.5%的重复基因,显示出高完整性和单倍体分辨率。这一举措与其他可用的丽蝇基因组相结合,将有助于持续努力了解丽蝇寄生行为的进化起源和分子基础。此外,它还将有助于制定害虫管理策略,以控制这种有害寄生虫的传播和影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4198/12369382/a1c5a8db7d9e/evaf121f1.jpg

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