膦酸衍生物的体外细胞抑制活性。
Cytostatic activity in vitro of phosphonic acid derivatives.
作者信息
Duś D, Wojdat E, Radzikowski C, Mastalerz P
出版信息
Arch Immunol Ther Exp (Warsz). 1985;33(2):325-9.
PMID:4084009
Abstract
Cytostatic activity of 48 new amino acid analogs and derivatives of phosphonic acid type was tested against KB cell line in vitro. The tests were performed according to the recommended international protocol for screening of chemical agents against tissue culture system. Three of the compounds tested: No. No, 29, 33 and 32 revealed cytostatic activity at the concentrations: 63, 150, and 180 micrograms ml-1 respectively (ID50).
摘要
测试了48种新型氨基酸类似物及膦酸型衍生物对KB细胞系的体外细胞生长抑制活性。测试按照针对组织培养系统筛选化学试剂的推荐国际方案进行。所测试的三种化合物：编号29、33和32分别在浓度63、150和180微克/毫升（半数抑制浓度）时显示出细胞生长抑制活性。
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