Mordarska H, Smogór W, Gamian A
Arch Immunol Ther Exp (Warsz). 1985;33(4):523-30.
Two specific glycolipids identified as monomannosyl diglyceride (G1) and monoacylated glucose (G2), isolated from Nocardiopsis dassonvillei strains, were found to be biologically active. They elicited antibody response in rabbits when administered with some carrier components: lecithine, methylated bovine serum albumin (MBSA) and Freund incomplete adjuvant (FIA). Antibodies to the glycolipids were detected in antisera to G1 and in the sera against crude cell antigen of N. dassonvillei (N). The ability of the lipids to induceskin delayed hypersensitivity (SDH) as well as adjuvant and mitogenic effect were also studied. Generally glycolipid G1 seemed to be more active in antibody response whereas glycolipid G2 was a better stimulator of cellular response. Glycolipid G2 appeared to be distinct adjuvant and mitogenic factor.
从达松维尔诺卡氏菌菌株中分离出的两种特定糖脂，即单甘露糖基甘油二酯（G1）和单酰化葡萄糖（G2），被发现具有生物活性。当与某些载体成分（卵磷脂、甲基化牛血清白蛋白（MBSA）和弗氏不完全佐剂（FIA））一起给药时，它们能在兔子体内引发抗体反应。在针对G1的抗血清以及针对达松维尔诺卡氏菌（N）粗细胞抗原的血清中检测到了针对这些糖脂的抗体。还研究了这些脂质诱导迟发型超敏反应（SDH）的能力以及佐剂和促有丝分裂作用。一般来说，糖脂G1在抗体反应中似乎更具活性，而糖脂G2是细胞反应的更好刺激剂。糖脂G2似乎是一种独特的佐剂和促有丝分裂因子。
