Svartling N, Pfäffli P, Tarkkanen L
Arch Orthop Trauma Surg (1978). 1985;104(4):242-6. doi: 10.1007/BF00450218.
The blood levels of monomeric methylmethacrylate were measured in 20 patients with fracture of the femoral neck, treated with a Thompson prosthesis under spinal anesthesia. Monomeric methylmethacrylate was detected in the blood stream in all patients; the maximum levels (mean 6.44 micrograms/ml, range 0.05-31.89 micrograms/ml) were measured 30 s after insertion of the Thompson prosthesis. A moderate drop in systolic blood pressure and a marked reduction of arterial oxygen tension was noted after cementation and insertion of the prosthesis; the mean maximum drops were 10.1 mm Hg (range 0-32 mm Hg) and 6.1 mm Hg (range 0-13.5 mm Hg) No dose-dependent correlation could be established between the levels of monomeric methylmethacrylate and the drop in arterial blood pressure or arterial oxygen tension.
对20例接受脊髓麻醉下汤普森假体治疗的股骨颈骨折患者，测定其血液中单体甲基丙烯酸甲酯的水平。所有患者血液中均检测到单体甲基丙烯酸甲酯；在插入汤普森假体30秒后测得最高水平（平均6.44微克/毫升，范围0.05 - 31.89微克/毫升）。在骨水泥固定和假体插入后，观察到收缩压适度下降以及动脉血氧张力显著降低；平均最大降幅分别为10.1毫米汞柱（范围0 - 32毫米汞柱）和6.1毫米汞柱（范围0 - 13.5毫米汞柱）。在单体甲基丙烯酸甲酯水平与动脉血压下降或动脉血氧张力下降之间未发现剂量依赖性相关性。
