Dolgova M A, Kul'bakh O S, Podosinnikov I S
Arkh Anat Gistol Embriol. 1985 Oct;89(10):71-6.
Development of pregnancy results in a systemic reaction of the immunogenetic organs: the structure of both the central (thymus) and peripheral lymphoid organs (lymph nodes) undergoes certain changes, beginning from its earliest stages (preimplantation period). Unidirection of the processes in the iliac (that are regional for the uterus) and mesenteric lymph nodes is stated. The reconstruction of the node occurs according to the reaction type at tissue allotransplantation, when hypertrophy of the thymus-dependent zone comes forward. During the period of the greatest manifestations of these alterations, however (the second half of pregnancy) the migration process of lymphocytes from blood into the lymph node is significantly inhibited. This is essentially clear in the iliac lymph nodes. The reconstruction of the thymus is in general similar with phenomena of accidental involution. However, accumulation of thymocytes in the medulla demonstrates blocking of their discharge into the blood stream. The disturbed processes of recirculation of result in incompleteness of the immune response at pregnancy and, perhaps, are included into the protective mechanisms of the offspring reproduction.
从最早阶段（植入前期）开始，中枢（胸腺）和外周淋巴器官（淋巴结）的结构都会发生一定变化。已表明在髂骨（子宫的区域淋巴结）和肠系膜淋巴结中这些过程具有单向性。淋巴结的重建按照组织同种异体移植时的反应类型进行，此时胸腺依赖区会出现肥大。然而，在这些改变最明显的时期（妊娠后半期），淋巴细胞从血液迁移到淋巴结的过程会受到显著抑制。这在髂骨淋巴结中尤为明显。胸腺的重建总体上与意外退化现象相似。然而，髓质中胸腺细胞的积累表明它们向血流中的释放受到了阻碍。再循环过程的紊乱导致妊娠时免疫反应不完整，并且可能被纳入后代生殖的保护机制中。
