Forster P M, McLean J M, Gibbs A C
J Anat. 1979 Jun;128(Pt 4):837-45.
Differences in weight, while cell density and differential white cell count of the thymus, spleen, iliac and popliteal lymph nodes of virgin, 10 days outbred pregnant, 10 days inbred pregnant, 10 days pseudopregnant, and 40 days outbred post-coitum rat were examined. Compared with virgin animals, significant weight gain occurred only in the thymus, spleen and iliac lymph nodes of the outbred group. Significant weight loss from the thymus and iliac nodes, and significant reductions in white cell density of the spleen and popliteal nodes occurred in delivered animals when compared with the virgin group. During pseudopregnancy significant weight loss occurred from the thymus, spleen and popliteal lymph nodes compared with the inbred group, and from the iliac lymph nodes compared with the virgin group. No significant differences were observed between the proportions of proliferating cells in the lymphocyte populations of the thymus, spleen, iliac and popliteal lymph nodes of the virgin group. In the outbred group the proliferating populations of all four tissues rose significantly above virgin levels, while in the inbred group only the iliac lymph nodes showed any significant rise above the virgin value. These findings are discussed in relation to the maternal immunological response to pregnancy.
对未交配的、远交系怀孕10天、近交系怀孕10天、假孕10天以及远交系交配后40天的大鼠的体重、胸腺、脾脏、髂淋巴结和腘淋巴结的细胞密度及白细胞分类计数进行了检测。与未交配动物相比，仅远交系组的胸腺、脾脏和髂淋巴结出现显著体重增加。与未交配组相比，分娩后的动物胸腺和髂淋巴结显著减重，脾脏和腘淋巴结白细胞密度显著降低。与近交系组相比，假孕期间胸腺、脾脏和腘淋巴结显著减重，与未交配组相比，髂淋巴结显著减重。未交配组胸腺、脾脏、髂淋巴结和腘淋巴结淋巴细胞群体中增殖细胞比例未见显著差异。远交系组所有四个组织的增殖群体均显著高于未交配水平，而近交系组仅髂淋巴结显著高于未交配值。结合母体对妊娠的免疫反应对这些发现进行了讨论。
