Dreschler W A, vd Hulst R J, Tange R A, Urbanus N A
Audiology. 1985;24(6):387-95. doi: 10.3109/00206098509078358.
Ototoxicity is one of the unwanted side-effects of a number of medical drugs. As ototoxicity appears to be most pronounced in the higher frequencies, it can be assessed at an earlier stage by using high-frequency audiometry from 8 to 20 kHz. We have investigated the precision of these measurements. In spite of inaccuracies of headphone positioning, which may influence especially the high-frequency thresholds, standard deviations for frequencies above 8 kHz were obtained that were nearly as small as for audiometry up to 8 kHz. Age-related reference curves for the higher frequencies are presented. The results on 100 ears of patients treated with platinum-derivatives show the importance of high-frequency audiometry for the early detection of ototoxicity.
耳毒性是许多药物的不良副作用之一。由于耳毒性在较高频率时似乎最为明显，因此可以通过使用8至20kHz的高频听力测定法在更早阶段进行评估。我们研究了这些测量的精度。尽管耳机定位存在不准确性，这可能尤其影响高频阈值，但对于8kHz以上的频率仍获得了标准差，其大小几乎与高达8kHz的听力测定法相同。给出了较高频率的年龄相关参考曲线。对100例接受铂类衍生物治疗患者的耳朵的研究结果表明，高频听力测定法对于早期发现耳毒性具有重要意义。
