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Lowering Blood Pressure, Raising Cancer Risk?: Evidence From Randomized Clinical Trials and Genetic Studies.

作者信息

Mannan Fahmida, Pigeyre Marie

机构信息

Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom; Division of Medicine and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.

Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

出版信息

JACC CardioOncol. 2025 Aug;7(5):624-626. doi: 10.1016/j.jaccao.2025.04.004.

DOI:10.1016/j.jaccao.2025.04.004
PMID:40841111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12441621/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4325/12441621/756ab0bbd85d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4325/12441621/756ab0bbd85d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4325/12441621/756ab0bbd85d/ga1.jpg

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本文引用的文献

1
Blood Pressure Lowering and Risk of Cancer: Individual Participant-Level Data Meta-Analysis and Mendelian Randomization Studies.血压降低与癌症风险：个体参与者水平数据的荟萃分析和孟德尔随机化研究
JACC CardioOncol. 2025 Aug;7(5):609-623. doi: 10.1016/j.jaccao.2025.03.005. Epub 2025 May 13.
2
The relationship between blood pressure and risk of renal cell carcinoma.血压与肾细胞癌风险的关系。
Int J Epidemiol. 2022 Aug 10;51(4):1317-1327. doi: 10.1093/ije/dyac042.
3
Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis.
遗传中介的抗高血压药物靶点治疗抑制与常见癌症风险：一项孟德尔随机化分析。
PLoS Med. 2022 Feb 3;19(2):e1003897. doi: 10.1371/journal.pmed.1003897. eCollection 2022 Feb.
4
Blood pressure and risk of cancer: a Mendelian randomization study.血压与癌症风险：一项孟德尔随机化研究。
BMC Cancer. 2021 Dec 16;21(1):1338. doi: 10.1186/s12885-021-09067-x.
5
Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis.抗高血压治疗与癌症风险：一项个体参与者数据荟萃分析。
Lancet Oncol. 2021 Apr;22(4):558-570. doi: 10.1016/S1470-2045(21)00033-4.
6
Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.血压与欧洲癌症前瞻性调查和营养中的癌症风险。
Int J Cancer. 2020 May 15;146(10):2680-2693. doi: 10.1002/ijc.32576. Epub 2019 Aug 20.
7
Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies.血压与癌症发展风险的关联：观察性研究的系统评价和荟萃分析。
Sci Rep. 2019 Jun 12;9(1):8565. doi: 10.1038/s41598-019-45014-4.
8
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.阅读孟德尔随机化研究：临床医生指南、词汇表和清单。
BMJ. 2018 Jul 12;362:k601. doi: 10.1136/bmj.k601.
9
The renin-angiotensin system and cancer: old dog, new tricks.肾素-血管紧张素系统与癌症：老调重弹。
Nat Rev Cancer. 2010 Nov;10(11):745-59. doi: 10.1038/nrc2945. Epub 2010 Oct 22.
10
Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials.血管紧张素受体阻断剂与癌症风险：随机对照试验的荟萃分析。
Lancet Oncol. 2010 Jul;11(7):627-36. doi: 10.1016/S1470-2045(10)70106-6. Epub 2010 Jun 11.