给予三碘甲状腺原氨酸对心脏和肾脏丙酮酸脱氢酶复合体对48小时饥饿反应的影响。
Effects of administration of tri-iodothyronine on the response of cardiac and renal pyruvate dehydrogenase complex to starvation for 48 h.
作者信息
Holness M J, Palmer T N, Sugden M C
出版信息
Biochem J. 1985 Nov 15;232(1):255-9. doi: 10.1042/bj2320255.
Abstract
Effects of administration of tri-iodothyronine (T3) on activities of cardiac and renal pyruvate dehydrogenase complex (active form, PDHa) were investigated. In fed rats, T3 treatment did not affect cardiac or renal PDHa activity, although blood non-esterified fatty acid and ketone-body concentrations were increased. Starvation (48 h) of both control and T3-treated rats resulted in similar increases in the steady-state concentrations of fatty acids and ketone bodies, but inactivation of cardiac and renal pyruvate dehydrogenase complex activities was diminished by T3 treatment. Inhibition of lipolysis increased renal and cardiac PDHa in control but not in T3-treated 48 h-starved rats, despite decreased fatty acid and ketone-body concentrations in both groups. The results suggest that hyperthyroidism influences the response of cardiac and renal PDHa activities to starvation through changes in the metabolism of lipid fuels in these tissues.
摘要
研究了三碘甲状腺原氨酸（T3）给药对心脏和肾脏丙酮酸脱氢酶复合物（活性形式，PDHa）活性的影响。在喂食的大鼠中，T3处理不影响心脏或肾脏的PDHa活性，尽管血液中非酯化脂肪酸和酮体浓度增加。对照大鼠和经T3处理的大鼠饥饿（48小时）均导致脂肪酸和酮体稳态浓度出现类似增加，但T3处理可减少心脏和肾脏丙酮酸脱氢酶复合物活性的失活。在对照大鼠中，抑制脂解可增加肾脏和心脏的PDHa，但在经T3处理的饥饿48小时大鼠中则不然，尽管两组的脂肪酸和酮体浓度均降低。结果表明，甲状腺功能亢进通过改变这些组织中脂质燃料的代谢来影响心脏和肾脏PDHa活性对饥饿的反应。
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