Levene C I, Carrington M J
Biochem J. 1985 Nov 15;232(1):293-6. doi: 10.1042/bj2320293.
Lathyrogens decrease collagen and elastin cross-linking by inhibiting lysine oxidase. The lathyrogens isoniazid and semicarbazide decrease liver pyridoxal phosphate and are teratogenic; all their effects are reversed by pyridoxal. beta-Aminopropionitrile, another lathyrogen, does not affect liver pyridoxal phosphate, and its lathyrogenic and teratogenic effects are not reversed by pyridoxal. Time courses of these effects differ greatly, suggesting enzyme inhibition by different mechanisms.
致畸形因素通过抑制赖氨酸氧化酶减少胶原蛋白和弹性蛋白的交联。致畸形因素异烟肼和氨基脲会降低肝脏磷酸吡哆醛水平且具有致畸性；它们的所有作用均可被磷酸吡哆醛逆转。另一种致畸形因素β-氨基丙腈不会影响肝脏磷酸吡哆醛水平，其致畸作用也不会被磷酸吡哆醛逆转。这些作用的时间进程差异很大，表明是通过不同机制抑制酶的活性。
