Sakurai T, Abe M, Hori S, Matsuda M
J Nutr Sci Vitaminol (Tokyo). 1981;27(6):529-38. doi: 10.3177/jnsv.27.529.
The in vivo effects of semicarbazide (SC) and aminooxyacetic acid (AOAA) on the B6 vitamer concentrations in brain subcellular fractions, especially in extrasynaptosomal, synaptosomal plasma, extrasynaptosomal and synaptosomal mitochondria, were investigated. Treatment of mice with SC decreased levels of pyridoxal phosphate (PLP) in extrasynaptosomal and synaptosomal plasma, while it had no effect on those in extrasynaptosomal and synaptosomal mitochondria. On the contrary, treatment with AOAA more significantly decreased pyridoxamine phosphate (PMP) levels in extrasynaptosomal and synaptosomal mitochondria than those in extrasynaptosomal and synaptosomal plasma. According to these results, the difference between in vivo effects of SC and AOAA on vitamin B6-enzymes was discussed.
研究了氨基脲（SC）和氨基氧乙酸（AOAA）对脑亚细胞组分，特别是突触体外、突触体血浆、突触体外和突触体线粒体中维生素B6各成分浓度的体内影响。用SC处理小鼠会降低突触体外和突触体血浆中磷酸吡哆醛（PLP）的水平，但对突触体外和突触体线粒体中的PLP水平没有影响。相反，用AOAA处理时，突触体外和突触体线粒体中磷酸吡哆胺（PMP）水平的降低比突触体外和突触体血浆中的更显著。根据这些结果，讨论了SC和AOAA对维生素B6酶的体内作用差异。
