Fazeli Moghadam E, Samadi M, Mohammadi S, Yarizadeh H, Abbasnezhad A
Nutritional Health Research Center, Nutrition, School of Health and Nutrition Lorestan University of Medical Sciences Khorramabad Iran.
Department of Nutrition, School of Nutrition Sciences and Food Technology Kermanshah University of Medical Sciences Kermanshah Iran.
Food Sci Nutr. 2025 Aug 19;13(8):e70742. doi: 10.1002/fsn3.70742. eCollection 2025 Aug.
Despite the connotations between some dietary patterns and irritable bowel syndrome (IBS), we are aware of no study about the link between IBS and patterns of nutrient intake. This study aimed to investigate the association between nutrient-based dietary patterns and IBS in the Iranian adult population. This multicenter case-control study was conducted across three states in the west of Iran from 2021 to 2023. In this study, 317 patients with IBS and 601 healthy people were selected from the companions of other patients as a control group. Participants' dietary habits were evaluated using the validated and reliable 168-item food frequency questionnaire (FFQ). The severity of extra-intestinal IBS symptoms was measured using the Extra-Intestinal Symptoms Severity Scale (EISSS). Three nutrient patterns were as follows: The first nutrient pattern was high in β-carotene, vitamin C, vitamin A, α-carotene, lutein, beta-cryptoxanthin, lycopene, and vitamin E. The second nutrient pattern was rich in maltose, total fiber, glucose, and fructose. The third nutrient pattern included high consumption of sugars, sucrose, galactose, lactose, and caffeine. Logistic regression analysis after adjusting for the confounding variables showed that participants with higher adherence to pattern I (OR 0.75, 95% CI 0.62-0.92, value 0.00) and pattern II (OR 0.52, 95% CI 0.42-0.64, value 0.00) had lower odds of IBS. However, there was no significant connection between the third nutrient pattern and IBS (OR 0.95, 95% CI 0.80-1.12, value > 0.05). Our study found that following nutrient patterns high in antioxidants, as well as those rich in monosaccharides and fiber, was primarily associated with lower odds of IBS.
尽管某些饮食模式与肠易激综合征（IBS）之间存在关联，但我们并未发现有关IBS与营养素摄入模式之间联系的研究。本研究旨在调查伊朗成年人群中基于营养素的饮食模式与IBS之间的关联。这项多中心病例对照研究于2021年至2023年在伊朗西部的三个州进行。在本研究中，从其他患者的同伴中选取了317例IBS患者和601名健康人作为对照组。使用经过验证且可靠的168项食物频率问卷（FFQ）评估参与者的饮食习惯。使用肠外症状严重程度量表（EISSS）测量肠外IBS症状的严重程度。三种营养素模式如下：第一种营养素模式富含β-胡萝卜素、维生素C、维生素A、α-胡萝卜素、叶黄素、β-隐黄质、番茄红素和维生素E。第二种营养素模式富含麦芽糖、总纤维、葡萄糖和果糖。第三种营养素模式包括高糖、蔗糖、半乳糖、乳糖和咖啡因的摄入量。在对混杂变量进行调整后的逻辑回归分析显示，对模式I（比值比0.75，95%置信区间0.62 - 0.92，P值0.00）和模式II（比值比0.52，95%置信区间0.42 - 0.64，P值0.00）依从性较高的参与者患IBS的几率较低。然而，第三种营养素模式与IBS之间没有显著关联（比值比0.95，95%置信区间0.80 - 1.12，P值>0.05）。我们的研究发现，遵循富含抗氧化剂以及富含单糖和纤维的营养素模式主要与较低的IBS患病几率相关。
