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1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板活化因子）在体外刺激植物氢离子运输和生长。

1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth.

作者信息

Scherer G F

出版信息

Biochem Biophys Res Commun. 1985 Dec 31;133(3):1160-7. doi: 10.1016/0006-291x(85)91258-6.

DOI:10.1016/0006-291x(85)91258-6
PMID:4084306
Abstract

1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor = PAF), a lipid with hormone-like properties in mammals, strongly stimulated ATP-dependent H+ transport in microsomes from zucchini hypocotyls. Stimulation of the maximal delta pH was 50-80% under optimal conditions at about 8 microM and growth was stimulated to about 20% at 2-4 microM 1-alkyl-2 acetyl-sn-glycero-3-phosphocholine. The effect on in vitro H+ transport was strongly dependent on the presence of phosphate. Chloride and nitrate were ineffective. Low concentrations of calcium interfered with the effect of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine on in vitro H+ transport.

摘要

1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板活化因子=PAF），一种在哺乳动物中具有类激素特性的脂质，强烈刺激西葫芦下胚轴微粒体中依赖ATP的H⁺转运。在约8微摩尔的最佳条件下，最大pH变化的刺激率为50%-80%，在2-4微摩尔的1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱作用下，生长刺激率约为20%。对体外H⁺转运的影响强烈依赖于磷酸盐的存在。氯化物和硝酸盐无效。低浓度的钙会干扰1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱对体外H⁺转运的作用。

相似文献

1
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth.1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板活化因子）在体外刺激植物氢离子运输和生长。
Biochem Biophys Res Commun. 1985 Dec 31;133(3):1160-7. doi: 10.1016/0006-291x(85)91258-6.
2
Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells.人内皮细胞对血小板活化因子（1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）和1-烷基-2-乙酰基-sn-甘油的代谢
Biochim Biophys Acta. 1986 May 21;876(3):373-8. doi: 10.1016/0005-2760(86)90022-6.
3
A plant protein kinase and plant microsomal H(+) transport are stimulated by the ether phospholipid platelet-activating factor.植物蛋白激酶和植物微粒体 H(+)转运被醚磷脂血小板激活因子所刺激。
Plant Cell Rep. 1988 Dec;7(7):579-82. doi: 10.1007/BF00272762.
4
Platelet-activating factor (PAF) stimulates the PAF-synthesizing enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF synthesis in neutrophils.血小板活化因子（PAF）刺激中性粒细胞中PAF合成酶乙酰辅酶A：1-烷基-sn-甘油-3-磷酸胆碱O2-乙酰基转移酶以及PAF的合成。
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7557-61. doi: 10.1073/pnas.84.21.7557.
5
Platelet-activating factor stimulates prolactin release from dispersed rat anterior pituitary cells in vitro.
Endocrinology. 1989 Mar;124(3):1502-6. doi: 10.1210/endo-124-3-1502.
6
Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues.胆碱磷酸转移酶在大鼠不同组织中合成1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板活化因子和一种降压脂质）的过程。
Biochim Biophys Acta. 1981 Feb 23;663(2):545-56. doi: 10.1016/0005-2760(81)90182-x.
7
Acetylcholine-like effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ('platelet-activating factor') and its analogues in exocrine secretory glands.
Eur J Biochem. 1984 Oct 1;144(1):65-72. doi: 10.1111/j.1432-1033.1984.tb08431.x.
8
Formation of 1-alkyl-2-acetyl-sn-glycerols via the de novo biosynthetic pathway for platelet-activating factor. Characterization of 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase in rat spleens.通过血小板激活因子的从头生物合成途径形成1-烷基-2-乙酰基-sn-甘油。大鼠脾脏中1-烷基-2-乙酰基-sn-甘油-3-磷酸磷酸水解酶的特性。
J Biol Chem. 1988 Feb 5;263(4):1755-60.
9
Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid.1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱的酶促合成，一种具有降血压和抑制血小板聚集作用的脂质。
J Biol Chem. 1980 Nov 10;255(21):10256-60.
10
A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.青霉属 F33 代谢产物及其合成衍生物抑制乙酰辅酶 A：1-O- 烷基- sn-甘油-3-磷酸胆碱乙酰转移酶（血小板激活因子生物合成的关键酶）和角叉菜胶诱导的小鼠足肿胀。
Biochem Pharmacol. 2013 Sep 1;86(5):632-44. doi: 10.1016/j.bcp.2013.06.021. Epub 2013 Jun 28.

引用本文的文献

1
A plant protein kinase and plant microsomal H(+) transport are stimulated by the ether phospholipid platelet-activating factor.植物蛋白激酶和植物微粒体 H(+)转运被醚磷脂血小板激活因子所刺激。
Plant Cell Rep. 1988 Dec;7(7):579-82. doi: 10.1007/BF00272762.
2
The animal ether phospholipid platelet-activating factor stimulates acidification of the incubation medium by cultured soybean cells.动物醚磷脂血小板激活因子刺激培养的大豆细胞使孵育介质酸化。
Plant Cell Rep. 1988 Dec;7(7):575-8. doi: 10.1007/BF00272761.
3
A plant lipid and the platelet-activating factor stimulate ATP-dependent H(+) transport in isolated plant membrane vesicles.
一种植物脂质和血小板激活因子刺激分离的植物膜囊泡中 ATP 依赖性 H(+)转运。
Planta. 1987 Sep;172(1):127-30. doi: 10.1007/BF00403038.
4
A new set of regulatory molecules in plants: A plant phospholipid similar to platelet-activating factor stimulates protein kinase and proton-translocating ATPase in membrane vesicles.植物中的一组新的调节分子：一种类似于血小板激活因子的植物磷脂可刺激膜泡中的蛋白激酶和质子转运 ATP 酶。
Planta. 1988 Aug;175(2):241-53. doi: 10.1007/BF00392434.
5
Stimulation by auxin of phospholipase A in membrane vesicles from an auxin-sensitive tissue is mediated by an auxin receptor.生长素刺激生长素敏感组织的膜小泡中的磷脂酶 A 的作用是由生长素受体介导的。
Planta. 1991 Sep;185(2):209-14. doi: 10.1007/BF00194062.
6
Proton transport and phosphorylation of tonoplast polypeptides from zucchini are stimulated by the phospholipid platelet-activating factor.液泡膜多肽的质子转运和磷酸化受血小板激活因子磷脂小板的刺激。
Plant Physiol. 1992 Aug;99(4):1635-41. doi: 10.1104/pp.99.4.1635.
7
Activation of Plasma Membrane NADH Oxidase Activity by Products of Phospholipase A.通过磷脂酶 A 的产物激活质膜 NADH 氧化酶活性。
Plant Physiol. 1991 Aug;96(4):1314-20. doi: 10.1104/pp.96.4.1314.
8
Biosynthesis and biotransformation of ether lipids.醚脂类的生物合成与生物转化
Lipids. 1987 Nov;22(11):789-99. doi: 10.1007/BF02535533.