Saffar Soflaei Sara, Ekrad-Ferezghi Reza, Najjari Behnood, Mobasheri Mohammad, Mousavi Seyed Mohammad Reza, Pourdad Arash, Moohebati Mohsen, Ferns Gordon A, Sarabadani Javad, Esmaily Habibollah, Ghayour Mobarhan Majid
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
J Dent Res Dent Clin Dent Prospects. 2025 Jun 30;19(2):76-82. doi: 10.34172/joddd.025.41913. eCollection 2025 Jun.
Previous studies have reported inconsistent results on the relationship between the number of teeth and all-cause mortality. There are several confounding factors in this relationship, especially age. We investigated the relationship between the number of teeth and all-cause mortality among residents in Mashhad, Iran.
Of 9704 participants of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study conducted in this cohort study, 395 participants were randomly recruited for dental examination. Baseline characteristics, including age, sex, and status of marriage, employment, and education, were collected for all the participants. The number of teeth was recorded by a dentist who also undertook a full dental examination. Individuals were followed up every three years, over 10 years, for the incidence of death. Data were analyzed using SPSS 20, and a value of<0.05 was considered significant. The effect of confounders was reduced using multivariate logistic regression.
Among 387 eligible participants, the mean age was 48.60±8.24 years, and most were female. The number of teeth was significantly related to age (<0.001), marital status (=0.002), and educational attainment (=0.001). Over ten years of follow-up, 15 of the participants died. Among baseline variables, only age was significantly associated with death (=0.008). The number of teeth was significantly associated with all-cause mortality after adjustment for age, sex and marital status, employment, and educational attainment (=0.003, OR=0.926, 95% CI: 0.880‒0.974).
Number of teeth is an independent predictor of all-cause mortality, especially in older individuals.
先前的研究报告了牙齿数量与全因死亡率之间关系的不一致结果。这种关系存在几个混杂因素，尤其是年龄。我们调查了伊朗马什哈德居民牙齿数量与全因死亡率之间的关系。
在这项队列研究中，对马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）研究的9704名参与者进行了研究，随机招募了395名参与者进行牙科检查。收集了所有参与者的基线特征，包括年龄、性别、婚姻状况、就业和教育状况。由一名进行全面牙科检查的牙医记录牙齿数量。对个体进行为期10年、每三年一次的死亡发生率随访。使用SPSS 20进行数据分析，P值<0.05被认为具有统计学意义。使用多变量逻辑回归减少混杂因素的影响。
在387名符合条件的参与者中，平均年龄为48.60±8.24岁，大多数为女性。牙齿数量与年龄（P<0.001）、婚姻状况（P = 0.002）和教育程度（P = 0.001）显著相关。在十年的随访中，15名参与者死亡。在基线变量中，只有年龄与死亡显著相关（P = 0.008）。在对年龄、性别、婚姻状况、就业和教育程度进行调整后，牙齿数量与全因死亡率显著相关（P = 0.003，OR = 0.926，95%CI：0.880 - 0.974）。
牙齿数量是全因死亡率的独立预测因素，尤其是在老年人中。
