Lukac Dzana, Vojinovic Tanja, Dutta Pinaki, Lukac Hasib, Medenica Sanja, Dutta Arshiya, Delevic Mitar, Hot Sanela Abazovic, Abazovic Dzihan, Vukovic Jovana, Miljkovic Branislava
Clinical Center of Montenegro, Ljubljanska bb, Podgorica, Montenegro.
Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Pharmacol. 2025 Sep 1;57(5):338-343. doi: 10.4103/ijp.ijp_947_24. Epub 2025 Aug 22.
In this century, antimicrobial resistance (AMR) presents a major public health problem, because it is a leading cause of death worldwide. Antimicrobial resistance is caused by the overprescription of antibiotics as well as self-medication. In 2010, antibiotics were the most commonly prescribed medications according to the Montenegrin Institute of Public Health. To reduce side effects, improve treatment efficacy, and prevent AMR, it is necessary to have greater control and help formulating national and international level policies over antibiotic prescription and their use.
This research focuses on the analysis of requests for the dispensing of reserve antibiotics and the justification of their prescription and use.
In the Clinical Center of Montenegro, 174 requests for restricted antibiotics were retrospectively analyzed.
Data analysis of 174 requests for restricted antibiotics determined that an antibiogram has been performed in only 21.84% of cases, which means that there were 78.16% of cases of empirical antibiotic use. In 72.25% of cases, restricted antibiotics were included in therapy without prior use of unrestricted antimicrobial therapy.
Based on data analytics, it can be concluded that using restricted antibiotics in therapy is not completely in line with rational antibiotics implementation. Restricted antibiotics are used without culture sensitivity tests in more than 2/3rd of cases. Similarly, restricted antibiotics were used as first-line therapy.
在本世纪,抗菌药物耐药性(AMR)是一个重大的公共卫生问题,因为它是全球主要的死亡原因之一。抗菌药物耐药性是由抗生素的过度处方以及自我用药引起的。根据黑山公共卫生研究所的数据,2010年抗生素是最常被处方的药物。为了减少副作用、提高治疗效果并预防抗菌药物耐药性,有必要加强对抗生素处方及其使用的控制,并协助制定国家和国际层面的政策。
本研究重点分析储备抗生素的调配申请及其处方和使用的合理性。
对黑山临床中心174份受限抗生素申请进行回顾性分析。
对174份受限抗生素申请的数据分析表明,仅21.84%的病例进行了药敏试验,这意味着78.16%的病例为经验性使用抗生素。在72.25%的病例中,受限抗生素在未先使用非受限抗菌治疗的情况下就被纳入治疗。
基于数据分析可以得出结论,在治疗中使用受限抗生素并不完全符合合理使用抗生素的原则。超过三分之二的病例在没有进行培养敏感性试验的情况下使用了受限抗生素。同样,受限抗生素被用作一线治疗。