甘油三酯葡萄糖体重校正腰围指数与一般人群中风风险的关联：一项来自美国国家健康与营养检查调查（NHANES）的大型横断面研究。

Association between triglyceride glucose-weight-adjusted waist index and stroke risk in the general population: A large cross-sectional study from NHANES.

作者信息

Chu Quanhong, Shen Yaoyao, Liu Shimin, Rao Wei, Wen An, Wu Lingfeng, Cao Wenfeng

机构信息

Department of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases) No, 266 Fenghe North Avenue, Honggutan District, Nanchang, Jiangxi 330038, China; Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College. No, 266 Fenghe North Avenue, Honggutan District, Nanchang, Jiangxi 330038, China.

出版信息

J Stroke Cerebrovasc Dis. 2025 Oct;34(10):108434. doi: 10.1016/j.jstrokecerebrovasdis.2025.108434. Epub 2025 Aug 20.

DOI:10.1016/j.jstrokecerebrovasdis.2025.108434

PMID:40845993

Abstract

BACKGROUND

Insulin resistance (IR) is closely associated with stroke risk. The triglyceride glucose-weight-adjusted waist index (TyG-WWI) is a novel biomarker for IR estimation. However, the relationship between the TyG-WWI index and stroke risk in the general population remains unexplored. This study aims to explore the potential relationship between the TyG-WWI index and stroke risk in the general population.

METHODS

A total of 22,615 participants from the 1999-2018 NHANES programme were included in this study. Multivariate logistic regression models, restricted cubic spline regression, subgroup analyses and sensitivity analysis were performed to explore the relationship between the TyG-WWI index and stroke risk in the general population.

RESULTS

Among the 22,615 participants included in the study, 812 participants were identified as stroke patients. After adjusting for multiple confounders, multivariate logistic regression analyses indicated that each SD (standard deviation) increase in the TyG-WWI index was associated with a 15 % increase in the risk of stroke (OR: 1.15, 95 % CI: 1.01-1.32). The further restricted cubic spline analysis demonstrated a positive linear relationship between the TyG-WWI index and stroke risk (p for non-linearity: 0.149). Subgroup analysis showed a more pronounced association between the TyG-WWI index and stroke risk among younger participants and those without coronary heart disease. Finally, sensitivity analysis consistently confirmed the robustness of the study findings.

CONCLUSIONS

The findings indicate a positive linear relationship between the TyG-WWI index and stroke risk in the general population.

摘要

背景

胰岛素抵抗（IR）与中风风险密切相关。甘油三酯葡萄糖体重校正腰围指数（TyG-WWI）是一种用于评估IR的新型生物标志物。然而，一般人群中TyG-WWI指数与中风风险之间的关系仍未得到探索。本研究旨在探讨一般人群中TyG-WWI指数与中风风险之间的潜在关系。

方法

本研究纳入了1999 - 2018年美国国家健康与营养检查调查（NHANES）项目的22,615名参与者。进行多变量逻辑回归模型、受限立方样条回归、亚组分析和敏感性分析，以探讨一般人群中TyG-WWI指数与中风风险之间的关系。

结果

在纳入研究的22,615名参与者中，812名被确定为中风患者。在调整多个混杂因素后，多变量逻辑回归分析表明，TyG-WWI指数每增加1个标准差（SD），中风风险增加15%（比值比：1.15，95%置信区间：1.01 - 1.32）。进一步的受限立方样条分析表明TyG-WWI指数与中风风险之间存在正线性关系（非线性p值：0.149）。亚组分析显示，在年轻参与者和无冠心病的参与者中，TyG-WWI指数与中风风险之间的关联更为明显。最后，敏感性分析一致证实了研究结果的稳健性。