Moskowitz A S, Terman G W, Carter K R, Morgan M J, Liebeskind J C
Brain Res. 1985 Dec 30;361(1-2):46-51. doi: 10.1016/0006-8993(85)91273-9.
We have compared the analgesic, locomotor stimulatory and lethal effects of morphine in two strains of mice, C57BL/6BY and CXBK. The CXBK strain is known to be deficient in central opioid binding sites and to be less sensitive than the C57 strain to certain effects of morphine and endogenous opioids. We found that the CXBK strain was less sensitive than the C57s to the analgesic and locomotor effects of morphine, but did not significantly differ in regard to morphine's lethal effect. The strain differences in sensitivity to the analgesic and locomotor effects were not uniform. The CXBK strain was much less sensitive than the C57 strain to the analgesic effect but only moderately less sensitive to the locomotor stimulatory effect. These differences may relate to previously demonstrated strain differences in the amounts of mu 1 and mu 2 opioid binding in central nervous system areas thought to mediate these behaviors.
我们比较了吗啡在两种品系小鼠（C57BL/6BY和CXBK）中的镇痛、运动刺激和致死作用。已知CXBK品系中枢阿片类结合位点缺乏，且对吗啡和内源性阿片类的某些作用比C57品系更不敏感。我们发现，CXBK品系对吗啡的镇痛和运动作用比C57品系更不敏感，但在吗啡的致死作用方面没有显著差异。对镇痛和运动作用的敏感性品系差异并不一致。CXBK品系对镇痛作用比C57品系敏感得多，但对运动刺激作用仅中度不敏感。这些差异可能与先前证明的在被认为介导这些行为的中枢神经系统区域中μ1和μ2阿片类结合量的品系差异有关。
