Moskowitz Andrea S, Terman Gregory W, Liebeskind John C
Neuroscience Program,U.L.C.A., Los Angeles, CA 90024 U.S.A. Department of Psychology U.C.L.A., Los Angeles, CA 90024 U.S.A.
Pain. 1985 Sep;23(1):67-72. doi: 10.1016/0304-3959(85)90231-3.
Inescapable footshock is capable of differentially activating opioid- and non-opioid-mediated mechanisms of stress-induced analgesia in the rat, depending on the temporal and intensive parameters of its administration. In this study we compared the effects of opioid and non-opioid stress analgesia in two strains of mice, one known to be deficient in central opioid binding sites (CXBK) and one normal in this regard (C57BL/6BY). We found that although the C57 strain showed robust opioid and non-opioid stress analgesia, the CXBK strain only showed stress analgesia of the non-opioid type.
不可逃避的足部电击能够根据给药的时间和强度参数，以不同方式激活大鼠应激诱导镇痛的阿片类和非阿片类介导机制。在本研究中，我们比较了阿片类和非阿片类应激镇痛在两种小鼠品系中的作用，一种已知在中枢阿片类结合位点方面存在缺陷（CXBK），另一种在这方面正常（C57BL/6BY）。我们发现，虽然C57品系表现出强烈的阿片类和非阿片类应激镇痛作用，但CXBK品系仅表现出非阿片类类型的应激镇痛作用。
