Li Chun, Ma Weining, Shen Haitao, Hou Zhipeng, Chen Jing, Yang Liqun, Sun Wei
Department of Pediatrics, Shengjing hospital of China Medical University, Shenyang 110004, China.
Department of neurosurgery, Shengjing hospital of China Medical University, Shenyang 110022, China.
Colloids Surf B Biointerfaces. 2025 Dec;256(Pt 2):115059. doi: 10.1016/j.colsurfb.2025.115059. Epub 2025 Aug 19.
Brain gliomas, particularly glioblastoma (GBM), are a category of brain tumors that are challenging to treat and characterized by low survival rates. Despite improvements in existing treatment options, challenges such as drug resistance, tumor heterogeneity, and the impediment of the blood-brain barrier to effective drug delivery remain prevalent. In recent years, natural polysaccharide polymers have attracted increasing interest in the treatment of GBM owing to their biocompatibility and potential for targeted delivery. Polysaccharides exert their effects through multiple mechanisms, including the modulation of the tumor microenvironment, targeted delivery, immune regulation, and participation in controlled drug release systems, potentially enhancing the adaptability of chemotherapy and extending patient survival. Additionally, this review examines colloidal parameters and biointerface interactions-such as particle size, surface charge, hydrophilic-hydrophobic balance, and membrane adsorption-that govern nanocarrier stability and BBB penetration efficiency. The development of drug delivery platforms based on natural polysaccharides can effectively address the challenges associated with drug delivery, reducing toxicity to healthy tissues. This article evaluates advancements in the use of natural polysaccharides, including hyaluronic acid, chitosan, cellulose, alginate, and starch, in the treatment of brain glioma. It underscores their significant role in eliciting anti-tumor effects and facilitating drug delivery systems, with particular emphasis on the mechanistic contributions of these polysaccharides in drug delivery processes.
脑胶质瘤，尤其是胶质母细胞瘤（GBM），是一类难以治疗且生存率低的脑肿瘤。尽管现有治疗方案有所改进，但耐药性、肿瘤异质性以及血脑屏障对有效药物递送的阻碍等挑战仍然普遍存在。近年来，天然多糖聚合物因其生物相容性和靶向递送潜力，在GBM治疗中引起了越来越多的关注。多糖通过多种机制发挥作用，包括调节肿瘤微环境、靶向递送、免疫调节以及参与控释药物系统，有可能增强化疗的适应性并延长患者生存期。此外，本综述探讨了控制纳米载体稳定性和血脑屏障穿透效率的胶体参数和生物界面相互作用，如粒径、表面电荷、亲水 - 疏水平衡和膜吸附。基于天然多糖的药物递送平台的开发可以有效应对与药物递送相关的挑战，降低对健康组织的毒性。本文评估了包括透明质酸、壳聚糖、纤维素、藻酸盐和淀粉在内的天然多糖在脑胶质瘤治疗中的应用进展。强调了它们在引发抗肿瘤作用和促进药物递送系统方面的重要作用，特别强调了这些多糖在药物递送过程中的作用机制。
