作为抗疟药的伯氨喹修饰物。1. 伯氨喹的5-苯氧基衍生物。
Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine.
作者信息
Chen E H, Saggiomo A J, Tanabe K, Verma B L, Nodiff E A
出版信息
J Med Chem. 1977 Aug;20(8):1107-9. doi: 10.1021/jm00218a026.
PMID:408489
Abstract
Various 5-phenoxy derivatives of primaquine have been prepared which are more active and less toxic than the parent compound in murine and monkey antimalarial screens. An improved method for the phthalimido alkylation of amines is described.
摘要
已经制备了多种伯氨喹的5-苯氧基衍生物，在小鼠和猴子的抗疟筛选中，它们比母体化合物活性更高且毒性更低。本文描述了一种改进的胺的邻苯二甲酰亚胺烷基化方法。
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