Modifications of primiaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine.
作者信息
Tanabe K, Chen E H, Verma B L, Saggiomo A J, Nodiff E A
出版信息
J Med Chem. 1978 Jan;21(1):133-6. doi: 10.1021/jm00199a028.
PMID:412967
Abstract
A number of 5-phenylthio and 5-anilino derivatives of primaquine have been prepared which are less toxic but less active than primaquine itself in murine and monkey antimalarial screens. It is apparent that the toxicity of primaquine can be diminished by introduction at position 5 of phenylthio, anilino, or phenoxy groups. However, the best hope for concomitant retention of high activity would seem to reside with the phenoxy moieties.
摘要
相似文献
1
Modifications of primiaquine as antimalarials. 2. 5-Phenylthio and 5-anilino derivatives of primaquine.
J Med Chem. 1978 Jan;21(1):133-6. doi: 10.1021/jm00199a028.
2
Modifications of primaquine as antimalarials. 1. 5-Phenoxy derivatives of primaquine.作为抗疟药的伯氨喹修饰物。1. 伯氨喹的5-苯氧基衍生物。
J Med Chem. 1977 Aug;20(8):1107-9. doi: 10.1021/jm00218a026.
3
Synthesis of 2-substituted primaquine analogues as potential antimalarials.2-取代伯氨喹类似物作为潜在抗疟药的合成。
J Med Chem. 1978 Sep;21(9):995-8. doi: 10.1021/jm00207a030.
4
Peptide derivatives of primaquine as potential antimalarial agents.作为潜在抗疟药的伯氨喹肽衍生物。
J Med Chem. 1988 Apr;31(4):870-4. doi: 10.1021/jm00399a032.
5
Antimalarials. 13. 5-Alkoxy analogues of 4-methylprimaquine.抗疟药。13. 4-甲基伯氨喹的5-烷氧基类似物。
J Med Chem. 1982 Aug;25(8):964-8. doi: 10.1021/jm00350a016.
6
Synthesis of some 4-substituted 8-amino-6-methoxyquinolines as potential antimalarials.
J Med Chem. 1979 Jun;22(6):694-9. doi: 10.1021/jm00192a016.
7
Synthesis of 2-benzyloxy and 2-benzylthio analogues of primaquine as potential antimalarials.合成伯氨喹的2-苄氧基和2-苄硫基类似物作为潜在抗疟药。
J Med Chem. 1977 Oct;20(10):1349-51. doi: 10.1021/jm00220a025.
8
[Synthesis of 2-methyl-5-substituted phenoxy-primaquine and antimalarials activity].[2-甲基-5-取代苯氧基-伯氨喹的合成及其抗疟活性]
Yao Xue Xue Bao. 1990;25(3):167-72.
9
Modifications of primaquine as antimalarials. 3. 5-Phenoxy derivatives of primaquine.
J Med Chem. 1982 Sep;25(9):1097-101. doi: 10.1021/jm00351a018.
10
Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials.作为新型传播阻断抗疟药的伯氨喹咪唑烷-4-酮衍生物。
J Med Chem. 2005 Feb 10;48(3):888-92. doi: 10.1021/jm0494624.
引用本文的文献
1
Considerations about the structure-activity relationships of 8-aminoquinoline antimalarial drugs.关于8-氨基喹啉抗疟药物构效关系的思考。
Bull World Health Organ. 1981;59(3):459-62.
Zotero 插件