关于8-氨基喹啉抗疟药物构效关系的思考。
Considerations about the structure-activity relationships of 8-aminoquinoline antimalarial drugs.
作者信息
McChesney J D
出版信息
Bull World Health Organ. 1981;59(3):459-62.
Abstract
A discussion of the structure-activity relationships (SAR) of 8-aminoquinoline antimalarial drugs is presented. Consideration is given to the potential role of metabolic transformations in the in vivo activation of 8-aminoquinolines. It is emphasized that the mechanism of action of 8-aminoquinoline agents has not yet been established and thus any analysis of SAR must be speculative.
摘要
本文讨论了8-氨基喹啉抗疟药物的构效关系（SAR）。文中考虑了代谢转化在8-氨基喹啉体内活化过程中的潜在作用。需要强调的是，8-氨基喹啉类药物的作用机制尚未明确，因此对构效关系的任何分析都必然带有推测性。
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