Lacerenza Michele, Calcaterra Valeria, Rossi Virginia, Zanelli Sara, Buttafava Mauro, Sormani Maria Pia, Contini Davide, Torricelli Alessandro, Zuccotti Gianvincenzo
PIONIRS s.r.l, Milan, 20124, Italy.
Pediatric Department, Buzzi Children's Hospital, Milan, 20154, Italy.
Sci Rep. 2025 Aug 25;15(1):31171. doi: 10.1038/s41598-025-16639-5.
Lower respiratory tract infections (LRTIs) are a significant cause of morbidity and mortality in pediatric populations worldwide. This study examines cerebral oxygenation (StO) in children with LRTIs using Time-Domain Near-Infrared Spectroscopy (TD-NIRS) device (PIONIRS S.r.l., Milan, Italy), a non-invasive tool that allows for measurement of cerebral StOin real-time. An observational case-control study was conducted, including 60 participants: 30 patients with LRTIs and 30 age and sex matched controls. We evaluated the correlation between cerebral StO and various clinical and physiological parameters and we used a multivariate logistic regression analysis explore predictors of LRTI. Cerebral StO was one of the key and independent predictors of LRTIs (OR = 0.45, p = 0.002) suggesting it could be an additional parameter to record for better assessing the condition of LRTI patients. These findings highlight the role of TD-NIRS in providing deeper insights into brain oxygenation in pediatric patients, independent of peripheral measurements such as peripheral oxygen saturation (SpO).
下呼吸道感染（LRTIs）是全球儿童发病和死亡的重要原因。本研究使用时域近红外光谱（TD-NIRS）设备（意大利米兰的PIONIRS S.r.l.）对患有LRTIs的儿童进行脑氧合（StO）检测，该设备是一种可实时测量脑StO的非侵入性工具。开展了一项观察性病例对照研究，包括60名参与者：30例LRTIs患者和30名年龄及性别匹配的对照者。我们评估了脑StO与各种临床和生理参数之间的相关性，并使用多因素逻辑回归分析来探究LRTI的预测因素。脑StO是LRTIs的关键独立预测因素之一（OR = 0.45，p = 0.002），这表明它可能是一个额外需要记录的参数，以更好地评估LRTI患者的病情。这些发现凸显了TD-NIRS在深入了解儿科患者脑氧合方面的作用，而不受诸如外周血氧饱和度（SpO）等外周测量的影响。
