Calcaterra Valeria, Lacerenza Michele, Rossi Virginia, Zanelli Sara, Contini Davide, Amendola Caterina, Buttafava Mauro, Torricelli Alessandro, Zuccotti Gianvincenzo
Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy.
Pediatric Department, Buzzi Children's Hospital, Milan, Italy.
Acta Paediatr. 2025 Mar;114(3):515-525. doi: 10.1111/apa.17459. Epub 2024 Oct 19.
Current non-invasive near-infrared spectroscopy (NIRS) tissue oximetry suffers from suboptimal reproducibility over probe repositioning, hindering clinical threshold establishment. Time Domain-NIRS (TD-NIRS) offers higher precision but lacks sufficient paediatric data, preventing effective clinical application. We aimed to establish reference ranges for cerebral and mid-upper arm (MUA) tissue haemodynamics in paediatric subjects using TD-NIRS and explore correlations with auxological variables.
TD-NIRS measurements were conducted acquiring data from cerebral and MUA regions with the NIRSBOX tissue oximeter. Morphological and clinically relevant information were collected to explore potential correlations with TD-NIRS derived parameters.
TD-NIRS assessment was applied in 350 children (8.4 ± 5.0 years). Precision of TD-NIRS was demonstrated with standard deviations of 0.9% (StO) and 4.2 μM (tHb) for frontotemporal cerebral cortex, and 0.8% (StO) and 3.7 μM (tHb) for MUA. No user dependency was observed. The trends of values for cerebral and peripheral regions vary differently according to age and auxological parameters.
This study reports resting-state optical and haemodynamic values for a healthy paediatric population, providing a foundation for future investigations into clinically relevant deviations in these parameters. Furthermore, correlations with anthropometric and demographic values provide valuable insights for a deeper understanding of tissue haemodynamic evolution in childhood.
目前的无创近红外光谱（NIRS）组织血氧饱和度测定法在探头重新定位时再现性欠佳，阻碍了临床阈值的确定。时域近红外光谱（TD-NIRS）具有更高的精度，但缺乏足够的儿科数据，无法实现有效的临床应用。我们旨在使用TD-NIRS建立儿科受试者大脑和上臂中部（MUA）组织血流动力学的参考范围，并探讨与人体测量学变量的相关性。
使用NIRSBOX组织血氧仪从大脑和MUA区域采集数据，进行TD-NIRS测量。收集形态学和临床相关信息，以探索与TD-NIRS衍生参数的潜在相关性。
对350名儿童（8.4±5.0岁）进行了TD-NIRS评估。颞额叶皮质的TD-NIRS精度表现为，总血红蛋白（tHb）标准差为0.9%（血氧饱和度[StO]）和4.2μM，MUA的StO标准差为0.8%，tHb标准差为3.7μM。未观察到用户依赖性。大脑和外周区域的值的趋势根据年龄和人体测量学参数的不同而有所不同。
本研究报告了健康儿科人群的静息状态光学和血流动力学值，为未来对这些参数的临床相关偏差进行研究奠定了基础。此外，与人体测量和人口统计学值的相关性为深入了解儿童期组织血流动力学演变提供了有价值的见解。
