棒状噬菌体的热诱导突变体
Heat-inducible mutants of corynebacteriophage.
作者信息
Groman N, Laird W
出版信息
J Virol. 1977 Sep;23(3):587-91. doi: 10.1128/JVI.23.3.587-591.1977.
Abstract
Heat-inducible mutants of temperate cornebacteriophage beta and gamma, called temperature-sensitive repression (tsr) mutants, were isolated and characterized. Lysogens carrying these mutants were induced at 38 degrees C, produced a normal or slightly increased yield of phage, and underwent extensive lysis at this temperature. In some cases mutation to heat inducibility had altered the UV inducibility of the phage, the changes ranging from loss to enhancement of this trait. Complementation tests showed that all five beta-tsr strains had mutated in the same cistron and suggested that these mutations were in the gene responsible for repressor production.
摘要
分离并鉴定了温和型棒状噬菌体β和γ的热诱导突变体，即温度敏感型阻遏（tsr）突变体。携带这些突变体的溶原菌在38℃下被诱导，产生正常或略有增加的噬菌体产量，并在此温度下发生广泛裂解。在某些情况下，热诱导突变改变了噬菌体的紫外线诱导性，这种变化范围从该特性的丧失到增强。互补试验表明，所有五个β-tsr菌株都在同一顺反子中发生了突变，并表明这些突变位于负责阻遏物产生的基因中。
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