Wang Rui, Cui Wenguo, Chen Xinliang
The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China.
Research (Wash D C). 2025 Aug 21;8:0845. doi: 10.34133/research.0845. eCollection 2025.
Current molecular machines face substantial challenges in coordinating their actions in space and time to generate cell-like macroscopic motions. A recent study in introduced a light-responsive artificial DNA nanomachine based on liquid-liquid phase separation technology-photofluids. By applying different light stimuli for spatiotemporal control, this nanomachine system successfully mimics typical cellular behaviors such as division, deformation, pseudopod extension, and rotation at the macroscopic scale for the first time. This study represents an innovative pathway from energy conversion at the molecular level to cell-like motion at the macroscopic level.
当前的分子机器在协调其在空间和时间上的行动以产生类似细胞的宏观运动方面面临着巨大挑战。最近的一项研究引入了一种基于液-液相分离技术——光流体的光响应人工DNA纳米机器。通过应用不同的光刺激进行时空控制，该纳米机器系统首次在宏观尺度上成功模拟了典型的细胞行为，如分裂、变形、伪足延伸和旋转。这项研究代表了从分子水平的能量转换到宏观水平的类似细胞运动的创新途径。
