Khan Wahab, Kazi Naima, Ali Haider, Noor Burshra, Haleem Shifa, Khan Qaisar Ali, Verma Ravina
Khyber Teaching Hospital MTI KTH, Peshawar, Pakistan.
Khyber Girls Medical College, Peshawar, Pakistan.
Ann Med Surg (Lond). 2025 Apr 22;87(7):4532-4535. doi: 10.1097/MS9.0000000000003308. eCollection 2025 Jul.
Spindle cell carcinoma is a sporadic sarcomatoid neoplasm in the lung and pleura, comprising only 0.3-1.3% of all malignant lung neoplasms. This case highlights a rare case of aggressive spindle cell carcinoma in a young female patient with no risk factor.
A 20-year-old female patient with no other comorbidities presented with a chronic cough associated with hemoptysis and right-sided chest pain off and off. Auscultation of the lungs revealed decreased breath sounds over the left lung. X-ray chest and computed tomographic (CT) scan of the chest showed a round homogenous opacity in the left lung. A biopsy of the mass confirmed the diagnosis of spindle cell carcinoma with focal myogenic differentiation and infarctive necrosis.
Spindle cell carcinoma is often difficult to diagnose histologically as it usually shows pleomorphism, exhibits minor differentiation, and includes components such as sarcoma, fusiform, or giant cells.
Diagnosing spindle cell carcinoma of the lung could be challenging, especially in young patients with no other risk factors.
梭形细胞癌是一种发生于肺和胸膜的散发性肉瘤样肿瘤，仅占所有恶性肺肿瘤的0.3%-1.3%。本病例突出显示了一名无危险因素的年轻女性患者发生侵袭性梭形细胞癌的罕见情况。
一名20岁无其他合并症的女性患者，反复出现伴有咯血和右侧胸痛的慢性咳嗽。肺部听诊显示左肺呼吸音减弱。胸部X线和胸部计算机断层扫描（CT）显示左肺有一个圆形均匀密度影。对肿块进行活检确诊为伴有局灶性肌源性分化和梗死性坏死的梭形细胞癌。
梭形细胞癌在组织学上通常难以诊断，因为它通常表现出多形性，分化程度低，并且包含肉瘤、梭形或巨细胞等成分。
诊断肺梭形细胞癌可能具有挑战性，尤其是在没有其他危险因素的年轻患者中。
