ODR-10细胞外环2中的多态性框内缺失消除了对双乙酰的感知。
A polymorphic inframe deletion in the ODR-10 extracellular loop 2 abolishes diacetyl sensing.
作者信息
Mehraj Aatira, Mimbré Rémy, Pelletier Katie, Singh Varsha, Félix Marie-Anne
机构信息
Institut de Biologie de l'École Normale Supérieure, Paris, Île-de-France, France.
Department of Developmental Biology and Genetics, Indian Institute of Science, Bengaluru, India.
出版信息
MicroPubl Biol. 2025 Jul 26;2025. doi: 10.17912/micropub.biology.001722. eCollection 2025.
The wild strain DL226 carries a 30 bp inframe deletion in the gene coding for the diacetyl olfactory receptor. DL226 animals are defective for attraction to diacetyl but not to pyrrole, an unrelated odorant also sensed by AWA neurons. Using genome editing in the N2 background, we show that this inframe deletion is causal for the defect in diacetyl sensing. The deletion specifically removes the predicted ligand-binding extracellular loop 2 (ECL2).
野生型菌株DL226在编码双乙酰嗅觉受体的基因中存在一个30 bp的框内缺失。DL226动物对双乙酰的吸引力存在缺陷，但对吡咯没有缺陷，吡咯是一种同样由AWA神经元感知的无关气味剂。利用N2背景下的基因组编辑，我们表明这种框内缺失是双乙酰感知缺陷的原因。该缺失特异性地去除了预测的配体结合细胞外环2（ECL2）。
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