Nigam P K, Kamboj V P, Chandra H
Contraception. 1985 Nov;32(5):483-9. doi: 10.1016/0010-7824(85)90018-6.
Effect of long-term Centchroman (3,4,-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy)-phe nyl)-7-methoxy chroman) treatment on some estrogen-sensitive biochemical parameters in the genital organs of female rhesus monkey was studied. Centchroman treatment did not demonstrate any consistent pattern of stimulation or inhibition in any of the estrogen-sensitive biochemical parameters. However, glycogen recorded a gradual decline in uterus, cervix and vagina. The results thus indicate that Centchroman evoked a mixed response probably due to manifestations of both estrogenic and antiestrogenic properties.
研究了长期服用醋炔醚（3,4-反式-2,2-二甲基-3-苯基-4-p-（β-吡咯烷基乙氧基）-苯基）-7-甲氧基色满）对雌性恒河猴生殖器官中一些雌激素敏感生化参数的影响。醋炔醚处理在任何雌激素敏感生化参数中均未显示出一致的刺激或抑制模式。然而，子宫、宫颈和阴道中的糖原含量逐渐下降。因此，结果表明醋炔醚可能由于雌激素和抗雌激素特性的表现而引起混合反应。
