成年雌性恒河猴生殖器官中的碳水化合物代谢：抗着床剂炔诺酮长期治疗的影响
Carbohydrate metabolism in the genital organs of adult female rhesus monkeys: effect of prolonged treatment with centchroman, an antiimplantation agent.
作者信息
Wadhwa V, Singh M M, Kamboj V P
出版信息
Exp Clin Endocrinol. 1985 Dec;86(3):266-72. doi: 10.1055/s-0029-1210496.
PMID:4092739
Abstract
Weekly oral administration of centchroman at 1 and 2.5 mg/kg doses for 3, 6 or 12 months to adult female rhesus monkeys (Macaca mulatta) significantly decreased glycogen content and activity of phosphorylase, glucokinase, lactate dehydrogenase and glucose 6-phosphate dehydrogenase enzymes in all the genital tract tissues. In general, the inhibition was dose and time dependent. No effect was, however, observed in the liver and serum.
摘要
对成年雌性恒河猴（猕猴）每周口服1毫克/千克和2.5毫克/千克剂量的炔诺酮3、6或12个月，显著降低了所有生殖道组织中的糖原含量以及磷酸化酶、葡萄糖激酶、乳酸脱氢酶和葡萄糖6 - 磷酸脱氢酶的活性。总体而言，这种抑制作用呈剂量和时间依赖性。然而，在肝脏和血清中未观察到影响。
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