Carbohydrate metabolism in the genital organs of adult female rhesus monkeys: effect of prolonged treatment with centchroman, an antiimplantation agent.

Weekly oral administration of centchroman at 1 and 2.5 mg/kg doses for 3, 6 or 12 months to adult female rhesus monkeys (Macaca mulatta) significantly decreased glycogen content and activity of phosphorylase, glucokinase, lactate dehydrogenase and glucose 6-phosphate dehydrogenase enzymes in all the genital tract tissues. In general, the inhibition was dose and time dependent. No effect was, however, observed in the liver and serum.