Nigam P K, Malaviya B, Chowdhury S R, Kamboj V P, Chandra H
Contraception. 1985 Sep;32(3):283-99. doi: 10.1016/0010-7824(85)90052-6.
Effect of weekly oral administration of Centchroman (3,4-trans-2, 2-dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)-phenyl)-7-met hoxychroman) at 1 and 2.5 mg/kg for 12 months on plasma estradiol, progesterone, luteinizing hormone and follicle stimulating hormone of female rhesus monkeys was studied. Centchroman administration at both doses did not disturb the menstrual pattern of rhesus monkeys except for a prolongation of the first treatment cycle. The subsequent cycles were of normal duration. The general pattern of plasma estradiol, progesterone, luteinizing hormone and follicle stimulating hormone was not affected by Centchroman treatment. The basal and peak levels were similar in pretreatment, control and treatment cycles. The results clearly indicate that Centchroman treatment up to 1 year does not affect the hypothalamo-pituitary-ovarian axis in female rhesus monkeys.
研究了每周口服1毫克/千克和2.5毫克/千克的醋炔醚（3,4-反式-2,2-二甲基-3-苯基-4-（对-（β-吡咯烷基乙氧基）-苯基）-7-甲氧基色满）12个月对雌性恒河猴血浆雌二醇、孕酮、促黄体生成素和促卵泡激素的影响。两种剂量的醋炔醚给药除了第一个治疗周期延长外，并未扰乱恒河猴的月经模式。随后的周期持续时间正常。醋炔醚治疗未影响血浆雌二醇、孕酮、促黄体生成素和促卵泡激素的总体模式。预处理、对照和治疗周期的基础水平和峰值水平相似。结果清楚地表明，长达1年的醋炔醚治疗不会影响雌性恒河猴的下丘脑-垂体-卵巢轴。
