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小细胞外囊泡、其所含物质与氧化应激：青光眼诊断与治疗中新兴的生物标志物

Small extracellular vesicles, their cargo, and oxidative stress: emerging biomarkers for glaucoma diagnosis and treatment.

作者信息

Romero Francisco J, Diaz-Llopis Manuel

机构信息

Department of Emergency, Requena General Hospital, Requena 46340, Spain.

MediPark Clinic, Olten 4600, Switzerland.

出版信息

Extracell Vesicles Circ Nucl Acids. 2025 May 28;6(2):272-275. doi: 10.20517/evcna.2025.22. eCollection 2025.

DOI:10.20517/evcna.2025.22
PMID:40852591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12367457/
Abstract

The contribution commented on is a relevant bridging work between extracellular vesicles, oxidative stress, and proteomics (especially regarding biomarkers) research. The findings reported are promising but further point out one of the future directions for investigations in glaucoma and certainly other such complex diseases.

摘要

所评论的这项贡献是细胞外囊泡、氧化应激和蛋白质组学（特别是关于生物标志物）研究之间一项相关的桥梁性工作。所报道的研究结果很有前景，但进一步指出了青光眼以及其他此类复杂疾病未来研究方向之一。

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本文引用的文献

1
Unraveling the nexus of oxidative stress, ocular diseases, and small extracellular vesicles to identify novel glaucoma biomarkers through in-depth proteomics.深入蛋白质组学解析氧化应激、眼部疾病和小细胞外囊泡的关系，寻找新型青光眼生物标志物。
Redox Biol. 2024 Nov;77:103368. doi: 10.1016/j.redox.2024.103368. Epub 2024 Sep 21.
2
Small Extracellular Vesicles and Oxidative Pathophysiological Mechanisms in Retinal Degenerative Diseases.小细胞外囊泡与视网膜退行性疾病的氧化病理生理机制
Int J Mol Sci. 2024 Jan 28;25(3):1618. doi: 10.3390/ijms25031618.
3
Crosstalk between Oxidative Stress and Exosomes.氧化应激与外泌体的串扰。
Oxid Med Cell Longev. 2022 Aug 30;2022:3553617. doi: 10.1155/2022/3553617. eCollection 2022.
4
Oxidative Stress: Concept and Some Practical Aspects.氧化应激：概念与一些实际方面
Antioxidants (Basel). 2020 Sep 10;9(9):852. doi: 10.3390/antiox9090852.
5
The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis.氧化应激状态与开角型青光眼和剥脱性青光眼的关联：一项系统评价和荟萃分析
J Ophthalmol. 2019 Jan 15;2019:1803619. doi: 10.1155/2019/1803619. eCollection 2019.
6
Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis.慢性青光眼的氧化和抗氧化应激标志物：系统评价与荟萃分析
PLoS One. 2016 Dec 1;11(12):e0166915. doi: 10.1371/journal.pone.0166915. eCollection 2016.
7
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Blue light stress in retinal neuronal (R28) cells is dependent on wavelength range and irradiance.视网膜神经元（R28）细胞中的蓝光应激取决于波长范围和辐照度。
Eur J Neurosci. 2011 Aug;34(4):548-58. doi: 10.1111/j.1460-9568.2011.07790.x. Epub 2011 Jul 22.
9
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