Tang Binghua, Li Shengjie, Cao Wenjun, Sun Xinghuai
Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
J Ophthalmol. 2019 Jan 15;2019:1803619. doi: 10.1155/2019/1803619. eCollection 2019.
To systematically evaluate the associations between oxidative stress status and different types of glaucoma.
Systematic review and meta-analysis.
We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs). A funnel plot analysis and Egger's test were performed to assess potential publication bias.
Oxidative stress status was abnormal and different in patients with OAG (open-angle glaucoma) and EXG (exfoliation glaucoma).
Blood TAS (total antioxidant status) was lower in the OAG group than in the control group, with a mean difference of 0.580 mmol/L ( < 0.0001, 95% CI = -0.668 to -0.492). The aqueous humor SOD (superoxide dismutase), GPX (glutathione peroxidase), and CAT (catalase) levels were higher in the OAG group than in the control group, with mean differences of 17.989 U/mL ( < 0.0001, 95% CI = 14.579-21.298), 12.441 U/mL ( < 0.0001, 95% CI = 10.423-14.459), and 1.229 fmol/mL (=0.042, 95% CI = 0.043-2.414), respectively. Blood TAS was lower in the EXG group than in the control group, with a mean difference of 0.262 mmol/L ( < 0.0001, 95% CI = -0.393 to -0.132). However, there were no differences in blood TOS and aqueous humor TOS between the EXG group and the control group.
This meta-analysis indicates that OAG patients had a lower TAS in the blood and higher levels of SOD, GPX, and CAT in the aqueous humor, while EXG patients only had a decreased TAS in the blood.
系统评估氧化应激状态与不同类型青光眼之间的关联。
系统评价和荟萃分析。
我们检索了PubMed、EMBASE和科学网，以查找1990年1月1日至2016年11月30日期间用英文撰写的随机对照试验。采用随机效应模型来估计氧化应激状态以及加权平均差和95%置信区间（CI）。进行漏斗图分析和Egger检验以评估潜在的发表偏倚。
开角型青光眼（OAG）和剥脱性青光眼（EXG）患者的氧化应激状态异常且存在差异。
OAG组的血液总抗氧化状态（TAS）低于对照组，平均差为0.580 mmol/L（P<0.0001，95%CI = -0.668至-0.492）。OAG组房水中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPX）和过氧化氢酶（CAT）水平高于对照组，平均差分别为17.989 U/mL（P<0.0001，95%CI = 14.579 - 21.298）、12.441 U/mL（P<0.0001，95%CI = 10.423 - 14.459）和1.229 fmol/mL（P = 0.042，95%CI = 0.043 - 2.414）。EXG组的血液TAS低于对照组，平均差为0.262 mmol/L（P<0.0001，95%CI = -0.393至-0.132）。然而，EXG组与对照组之间的血液总氧化状态（TOS）和房水TOS没有差异。
这项荟萃分析表明，OAG患者血液中的TAS较低，房水中的SOD、GPX和CAT水平较高，而EXG患者仅血液中的TAS降低。
