Adeleye J O, Onasanya A S, Sonuga O O, Esan A, Adebiyi A A
Department of Medicine, College of Medicine, University of Ibadan/University College Hospital, Ibadan, Oyo State, Nigeria.
Department of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria.
Ann Ib Postgrad Med. 2025 Mar 31;23(1):112-120.
Low serum testosterone is reported to be common in men with type 2 diabetes mellitus (type 2 DM). However, the Endocrine society has recommended that the diagnosis of male hypogonadism be based on the presence of symptoms of testosterone deficiency in combination with low serum testosterone.
The aim of this study was to determine the frequency and correlates of hypogonadism in a cohort of Nigerian men with type 2 DM.
We studied 100 men with type 2 DM and 100 age matched non-diabetic men in a cross-sectional study. The Androgen Deficiency in the Aging Male (ADAM) questionnaire was administered to all study subjects. Anthropometric parameters, total testosterone, sex hormone binding globulin (SHBG), serum Gonadotrophins, glycated haemoglobin and lipid profile were measured. Serum free testosterone was calculated using Vermeulen's equation. Hypogonadism was considered present in men with symptoms of hypogonadism in combination with a low calculated free testosterone (cFT) < 0.255nmol/l. Data was analysed using SPSS 20 package with level of significance set at p value < 0.05.
41% of men with type 2 DM had hypogonadism, compared to 10% of non-diabetic men. Secondary hypogonadism was found in 22% of men with type 2 DM, while primary hypogonadism was present in 19%. Amongst hypogonadal men with type 2 DM, secondary hypogonadism was the underlying cause in 53.7%. Truncal obesity was identified as a significant independent predictor of hypogonadism.
Conclusion: This study demonstrated that hypogonadism was a common condition among men with type 2 DM. Truncal obesity emerged as a significant independent predictor of hypogonadism.
据报道，2型糖尿病（2型DM）男性中血清睾酮水平低很常见。然而，内分泌学会建议男性性腺功能减退的诊断应基于睾酮缺乏症状与低血清睾酮水平同时存在。
本研究的目的是确定一组尼日利亚2型糖尿病男性中性腺功能减退的发生率及其相关因素。
我们进行了一项横断面研究，研究对象为100名2型糖尿病男性和100名年龄匹配的非糖尿病男性。对所有研究对象进行了老年男性雄激素缺乏（ADAM）问卷调查。测量了人体测量参数、总睾酮、性激素结合球蛋白（SHBG）、血清促性腺激素、糖化血红蛋白和血脂谱。使用Vermeulen方程计算血清游离睾酮。性腺功能减退被定义为伴有性腺功能减退症状且计算出的游离睾酮（cFT）<0.255nmol/l的男性。使用SPSS 20软件包进行数据分析，显著性水平设定为p值<0.05。
2型糖尿病男性中有41%存在性腺功能减退，而非糖尿病男性中这一比例为10%。2型糖尿病男性中22%为继发性性腺功能减退，19%为原发性性腺功能减退。在2型糖尿病性腺功能减退男性中，继发性性腺功能减退是53.7%的潜在病因。躯干肥胖被确定为性腺功能减退的一个重要独立预测因素。
本研究表明，性腺功能减退在2型糖尿病男性中是一种常见情况。躯干肥胖是性腺功能减退的一个重要独立预测因素。
