Nakamura Tomoko, Abe Shinya, Yamazaki Hitoshi, Oiwake Toshihiko, Hayashi Atsushi
Department of Ophthalmology, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
J Ophthalmic Inflamm Infect. 2025 Aug 25;15(1):64. doi: 10.1186/s12348-025-00523-4.
Vogt-Koyanagi-Harada (VKH) disease affects visual function, but the recovery process of color vision remains incompletely understood. This study aimed to assess color vision recovery in VKH using cone contrast testing and explore its relationship with cone cell density measured using adaptive optics imaging.
Twenty-two eyes of 11 patients with VKH were evaluated at baseline (serous retinal detachment resolution) and at 3, 6, and 12 months post-treatment. Cone contrast scores and cone cell density were measured using the ColorDx CCT-HD™ system and rtx1™ adaptive optics fundus camera, respectively. Pre-treatment optical coherence tomography (OCT) was used to analyze the cystoid spaces.
Color vision defects observed at baseline-especially in S-cones-significantly improved by 6 months for all cone types. Cone contrast scores correlated significantly with cone cell density (ρ = 0.63-0.66, p < 0.0001). Eyes with cystoid spaces on pre-treatment OCT showed lower cone contrast scores and cone density. S-cones demonstrated greater vulnerability and slower recovery than L- and M-cones.
This study emphasizes the importance of comprehensive visual function assessment, including color vision evaluation, in VKH patients. Cone contrast testing captures qualitative aspects of visual function not reflected in standard acuity tests. The combination of cone contrast testing and adaptive optics imaging provides insights into the structure-function relationship in color vision recovery.
伏格特-小柳-原田（VKH）病会影响视觉功能，但色觉的恢复过程仍未完全明了。本研究旨在通过视锥细胞对比度测试评估VKH患者的色觉恢复情况，并探讨其与使用自适应光学成像测量的视锥细胞密度之间的关系。
对11例VKH患者的22只眼睛在基线时（浆液性视网膜脱离消退）以及治疗后3个月、6个月和12个月进行评估。分别使用ColorDx CCT-HD™系统和rtx1™自适应光学眼底相机测量视锥细胞对比度评分和视锥细胞密度。治疗前的光学相干断层扫描（OCT）用于分析囊样间隙。
基线时观察到的色觉缺陷——尤其是S视锥细胞的缺陷——在6个月时所有视锥细胞类型均有显著改善。视锥细胞对比度评分与视锥细胞密度显著相关（ρ = 0.63 - 0.66，p < 0.0001）。治疗前OCT显示有囊样间隙的眼睛视锥细胞对比度评分和视锥细胞密度较低。S视锥细胞比L视锥细胞和M视锥细胞表现出更大的易损性和更慢 的恢复速度。
本研究强调了在VKH患者中进行全面视觉功能评估（包括色觉评估）的重要性。视锥细胞对比度测试能够捕捉标准视力测试中未反映的视觉功能的定性方面。视锥细胞对比度测试与自适应光学成像相结合，为色觉恢复中的结构-功能关系提供了见解。
