White Kayla M, Livnat Itamar, Frambach Caroline R, Doan John, Mehta Urmi V, Yuh Clara, Palma Anton M, Jameson Kimberly A, Kenney M Cristina, Mehta Mitul C, Boisvert Chantal J, Crow Wade R, Browne Andrew W
School of Medicine, University of California, Irvine, CA, 92617, USA.
Case Western Reserve University Ophthalmology, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Int J Retina Vitreous. 2023 Feb 2;9(1):9. doi: 10.1186/s40942-023-00442-3.
Cone contrast threshold testing (CCT) provides quantitative measurements of color and contrast function to reveal changes in vision quality that are not standard endpoints in clinical trials. We utilize CCT to measure visual function in patients with multiple sclerosis (MS), age-related macular degeneration (AMD), epiretinal membrane (ERM), and retinal vein occlusion (RVO).
Retrospective data was gathered from 237 patients of the Gavin Herbert Eye Institute. Subjects included 17 patients with MS, 45 patients with AMD, 41 patients with ERM, 11 patients with RVO, and 123 healthy controls. Patients underwent the primary measurement outcome, CCT testing, as well as Sloan visual acuity test and spectral domain optical coherence tomography during normal care.
Color and contrast deficits were present in MS patients regardless of history of optic neuritis. AMD with intermediate or worse disease demonstrated reduced CCT scores. All 3 stages of ERM demonstrated cone contrast deficits. Despite restoration of visual acuity, RVO-affected eyes demonstrated poorer CCT performance than unaffected fellow eyes.
CCT demonstrates color and contrast deficits for multiple retinal diseases with differing pathophysiology. Further prospective studies of CCT in other disease states and with larger samples sizes is warranted.
视锥细胞对比度阈值测试（CCT）可对颜色和对比度功能进行定量测量，以揭示视力质量的变化，而这些变化并非临床试验中的标准终点。我们利用CCT来测量多发性硬化症（MS）、年龄相关性黄斑变性（AMD）、视网膜前膜（ERM）和视网膜静脉阻塞（RVO）患者的视觉功能。
从加文·赫伯特眼科研究所的237名患者中收集回顾性数据。研究对象包括17名MS患者、45名AMD患者、41名ERM患者、11名RVO患者和123名健康对照者。患者在常规护理期间接受了主要测量指标CCT测试，以及斯隆视力测试和光谱域光学相干断层扫描。
无论有无视神经炎病史，MS患者均存在颜色和对比度缺陷。中度或更严重疾病的AMD患者CCT评分降低。ERM的所有3个阶段均表现出视锥细胞对比度缺陷。尽管视力恢复，但受RVO影响的眼睛的CCT表现比未受影响的对侧眼差。
CCT显示了多种具有不同病理生理学的视网膜疾病的颜色和对比度缺陷。有必要在其他疾病状态下以及更大样本量中对CCT进行进一步的前瞻性研究。
