Terra J L, Patricot M C, Dalery J, Mathian B, Greffe J, Guyotat J
Encephale. 1985 Jul-Aug;11(4):171-4.
The authors report a study of 94 dexamethasone-suppression-tests conducted in a group of 29 patients with either a manic-depressive psychosis (n = 14) or a depressive symptomatology associated or not with a chronic psychotic disorder. 1 mg of dexamethasone was given orally at 11 p.m. and plasma cortisol levels were determined the following day at 4 p.m. The same day, a MADS was calculated. These tests were repeated every month for each patient independently of the clinical state. 9 patients received between 4 and 11 tests. A non suppression (cortisol plasma levels greater than or equal to 140 nmol/l) was observed in 27% of the tests. A comparable percentage was obtained in the whole group of patients and in the manic-depressive psychosis group. A good correlation appeared between plasma cortisol level at 4 p.m. and score for MADS. The study of the validity of the test shows a sensibility of 50% and a specificity of 85%. These results are similar with those presented in the literature.
作者报告了一项针对29名患者进行的94次地塞米松抑制试验的研究，这些患者患有躁郁症精神病（n = 14）或伴有或不伴有慢性精神障碍的抑郁症状。晚上11点口服1毫克地塞米松，次日下午4点测定血浆皮质醇水平。同一天，计算了躁狂抑郁评定量表（MADS）得分。每个患者每月独立重复这些测试，与临床状态无关。9名患者接受了4至11次测试。27%的测试中观察到无抑制（血浆皮质醇水平大于或等于140 nmol/l）。在整个患者组和躁郁症精神病组中获得了相当的百分比。下午4点的血浆皮质醇水平与MADS得分之间呈现出良好的相关性。对该测试有效性的研究显示敏感性为50%，特异性为85%。这些结果与文献中呈现的结果相似。
