Steardo L, Cardone G, Casiello M, Sorge F, Muscettola G
Acta Psychiatr Belg. 1984 May-Jun;84(3):218-27.
Plasma cortisol suppression following 1 mg dexamethasone administration was investigated in patients with affective disorders. Twenty-nine depressed outpatients, 8 bipolar depressed inpatients during manic or hypomanic phase, and twelve healthy volunteers entered the study. Depressed patients were divided into 2 groups according to Research Diagnostic Criterio of Spitzer et al. (1978). The first group consisted of 10 patients affected by minor depressive disorders. The second group was formed of 19 patients with major depressive disorders (7 bipolar, 12 unipolar). No difference between patients and controls was found in baseline 4.00 p.m. serum cortisol levels. Healthy volunteers, patients with minor depressive disorders and bipolar subjects in manic or hypomanic phase showed normal suppression. On the other hand, only 42% of patients with major depressive disorders showed suppression. These results suggest that altered response to dexamethasone is a state-dependent phenomenon. Moreover, a dexamethasone suppression test is able to identify subgroups of suppressor in affected patients.
在情感障碍患者中研究了给予1毫克地塞米松后血浆皮质醇的抑制情况。29名门诊抑郁症患者、8名处于躁狂或轻躁狂期的双相情感障碍住院抑郁症患者以及12名健康志愿者参与了该研究。根据斯皮策等人（1978年）的研究诊断标准，将抑郁症患者分为两组。第一组由10名患有轻度抑郁症的患者组成。第二组由19名患有重度抑郁症的患者组成（7名双相情感障碍患者，12名单相情感障碍患者）。下午4点的基线血清皮质醇水平在患者和对照组之间未发现差异。健康志愿者、轻度抑郁症患者以及处于躁狂或轻躁狂期的双相情感障碍患者表现出正常的抑制。另一方面，只有42%的重度抑郁症患者表现出抑制。这些结果表明，对地塞米松的反应改变是一种状态依赖性现象。此外，地塞米松抑制试验能够识别受影响患者中的抑制亚组。
