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Single-Nucleus RNA-Seq Reveals PTSD-Associated Transcriptional Changes in Dopaminergic Neurons of the Lateral VTA.

作者信息

Zhou Peiling, Yan Hongwei, Wu Jingtong, Lan Qinghui, Wang Xue-Min, Ding Jin-Jun, Wu Hai-Tao, Zhang Changzheng

机构信息

Guangdong Provincial Key Laboratory of Development and Education for Special Needs Children &, School of Educational Sciences, Lingnan Normal University, Zhanjiang, 524048, China.

Department of Emergency and Critical Disease, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

出版信息

Neurosci Bull. 2025 Aug 25. doi: 10.1007/s12264-025-01482-5.

DOI:10.1007/s12264-025-01482-5
PMID:40855030
Abstract
摘要

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Characterization of NTS-to-VTA projection neurons reveals higher-order synaptic organization and distinct responsiveness to cholecystokinin.孤束核到腹侧被盖区投射神经元的特征揭示了高阶突触组织和对胆囊收缩素的不同反应性。
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本文引用的文献

1
Role of ventral tegmental area dopamine neurons in fear memory retention in post-traumatic stress disorder model rats.中缝背核多巴胺神经元在创伤后应激障碍模型大鼠恐惧记忆保持中的作用。
J Psychiatr Res. 2024 Oct;178:59-65. doi: 10.1016/j.jpsychires.2024.08.003. Epub 2024 Aug 5.
2
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model.氟西汀挽救创伤后应激障碍模型中小鼠过度的髓鞘形成和心理行为。
Neurosci Bull. 2024 Aug;40(8):1037-1052. doi: 10.1007/s12264-024-01249-4. Epub 2024 Jul 16.
3
Mural cell composition and functional analysis in the healing process of human gingiva from periodontal intrabony defects.
人牙周内骨缺损愈合过程中龈壁细胞组成和功能分析。
Arch Oral Biol. 2023 Jun;150:105687. doi: 10.1016/j.archoralbio.2023.105687. Epub 2023 Mar 17.
4
Stressed and wired: The effects of stress on the VTA circuits underlying motivated behavior.压力与兴奋：压力对动机行为背后的腹侧被盖区神经回路的影响。
Curr Opin Endocr Metab Res. 2022 Oct;26. doi: 10.1016/j.coemr.2022.100388. Epub 2022 Aug 7.
5
An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1 vascular smooth muscle subtype involved in abdominal aortic aneurysm formation.节段间单细胞图谱揭示主动脉异质性，并鉴定出一种新型 Malat1 血管平滑肌亚型，其与腹主动脉瘤形成有关。
Signal Transduct Target Ther. 2022 Apr 27;7(1):125. doi: 10.1038/s41392-022-00943-x.
6
An atlas of transcriptionally defined cell populations in the rat ventral tegmental area.大鼠腹侧被盖区转录定义细胞群图谱。
Cell Rep. 2022 Apr 5;39(1):110616. doi: 10.1016/j.celrep.2022.110616.
7
Single-Cell Transcriptomics and Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway.单细胞转录组学和形态分析揭示了黑质纹状体通路上小胶质细胞的异质性。
Front Immunol. 2021 Mar 29;12:639613. doi: 10.3389/fimmu.2021.639613. eCollection 2021.
8
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.在百万退伍军人计划中，创伤后应激障碍及其症状亚类的全基因组关联分析。
Nat Genet. 2021 Feb;53(2):174-184. doi: 10.1038/s41588-020-00767-x. Epub 2021 Jan 28.
9
Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder.腹侧被盖区功能障碍和多巴胺平衡破坏：对创伤后应激障碍的影响。
Mol Neurobiol. 2021 May;58(5):2423-2434. doi: 10.1007/s12035-020-02278-6. Epub 2021 Jan 11.
10
Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex.大脑皮层中基因组印记的细胞类型特异性。
Neuron. 2020 Sep 23;107(6):1160-1179.e9. doi: 10.1016/j.neuron.2020.06.031. Epub 2020 Jul 23.