Ovsiannikov V I, Berezina T P, Anoshina A A, Samoshkin N P, Grishina O Iu
Fiziol Zh SSSR Im I M Sechenova. 1985 Nov;71(11):1413-8.
In acute experiments on cats, an isolated portion of the small intestine was vascularly perfused with arterial blood by means of the constant volume perfusion pump. Contractile activity of the ileal and/or jejunal segment was estimated by means of isometric tension. Activation of the myenteric cholinergic neurons as the result of the infusion of nicotinic cholinoreceptor agonist subecholine or electrical stimulation of the vagal efferents was followed by increased contractile response of intestinal smooth muscle to serotonin (2.5 X 10(-8) or 5.0 X 10(-9) mol). The same effect was observed after increasing endogenous acetylcholine concentration induced with application of anticholinesterase drug prozerin. The data obtained suggested that the modulating effect of acetylcholine might be of a certain physiological importance.
在对猫进行的急性实验中，通过恒容灌注泵用动脉血对小肠的一个孤立部分进行血管灌注。通过等长张力来评估回肠和/或空肠段的收缩活性。由于注入烟碱型胆碱能受体激动剂苏贝胆碱或电刺激迷走神经传出纤维而导致肌间胆碱能神经元激活后，肠道平滑肌对血清素（2.5×10⁻⁸或5.0×10⁻⁹摩尔）的收缩反应增强。在用抗胆碱酯酶药物毒扁豆碱增加内源性乙酰胆碱浓度后也观察到了相同的效果。所获得的数据表明乙酰胆碱的调节作用可能具有一定的生理重要性。
