Berezina T P, Ovsiannikov V I
Fiziol Zh SSSR Im I M Sechenova. 1983 Nov;69(11):1491-7.
In acute experiments on cats, an isolated portion of the ileum was vascularly perfused. Contractile activity of the ileum was estimated by isometric tension. The subthreshold dose of acetylcholine (6.10(-10) mol/ml, 1 ml/min) facilitated the contractile responses of the ileum induced by i.a. administration of serotonin (2.5 . 10(-8) or 5 . 10(-8) mol). Blockade of nicotinic receptors with benzohexonium (10 mg/kg) diminished the serotonin-induced contractile responses but did not affect the facilitating effect of acetylcholine. Blockade of muscarinic receptors with atropine (0.2 ml/kg) abolished the serotonin-induced responses. The facilitating effect of acetylcholine on the serotonin-induced contractile responses of the ileum seems to be actualized at postganglionic level of the intramural nervous plexus with the participation of muscarinic cholinoreceptors.
在对猫进行的急性实验中，对一段离体回肠进行血管灌注。通过等长张力评估回肠的收缩活性。阈下剂量的乙酰胆碱（6×10⁻¹⁰摩尔/毫升，1毫升/分钟）可促进经腹腔注射血清素（2.5×10⁻⁸或5×10⁻⁸摩尔）诱导的回肠收缩反应。用苯磺铵（10毫克/千克）阻断烟碱受体可减弱血清素诱导的收缩反应，但不影响乙酰胆碱的促进作用。用阿托品（0.2毫升/千克）阻断毒蕈碱受体可消除血清素诱导的反应。乙酰胆碱对血清素诱导的回肠收缩反应的促进作用似乎是在壁内神经丛的节后水平通过毒蕈碱胆碱受体实现的。
