Lavrova Z S, Ovsiannikov V I
Fiziol Zh SSSR Im I M Sechenova. 1985 Sep;71(9):1156-63.
In acute experiments on cats, an isolated portion of the small intestine was perfused with a constant blood flow pump. Contractile activity of the intestine was estimated by means of isometric tension. Arterial vessel reactions were reflected in perfusion pressure shifts. Responses of the venous section of the perfused vascular bed were recorded by means of accumulography technique. The subthreshold dose of histamine (10(-9) or 10(-7) g/ml, 0.8 ml/min) potentiated the contractile responses of the jejunum induced with i. a. administration of acetylcholine (0.1 X 10(-4) g). Blockade of nicotinic receptors with benzohexonium and H1-histamine receptors with suprastin did not affect the potentiating effect of histamine. Dilatatory responses of arterial vessels induced by acetylcholine could be either increased or decreased against the background of histamine. The drug did not modulate responses of the intestinal venous vessels however. The modulating effect of histamine on the acetylcholine-induced contractile responses of the jejunum seems to be actualized through the participation of H2-histamine receptors.
在对猫进行的急性实验中，用恒流泵对小肠的一个分离部分进行灌注。通过等长张力来估计肠道的收缩活动。动脉血管反应通过灌注压力变化来反映。通过累积描记术记录灌注血管床静脉段的反应。组胺的阈下剂量（10⁻⁹或10⁻⁷克/毫升，0.8毫升/分钟）增强了腹腔注射乙酰胆碱（0.1×10⁻⁴克）诱导的空肠收缩反应。用溴苄铵阻断烟碱受体和用苯海拉明阻断H1组胺受体并不影响组胺的增强作用。在组胺的背景下，乙酰胆碱诱导的动脉血管扩张反应可能增加或减少。然而，该药物并未调节肠道静脉血管的反应。组胺对乙酰胆碱诱导的空肠收缩反应的调节作用似乎是通过H2组胺受体的参与来实现的。
